Genetics and Epigenetics of the Skin Meet Deep Sequence

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2012 Jan 13

PMID 22237701

Citations 6

Authors

Jeffrey B Cheng

Raymond J Cho

Affiliations

Soon will be listed here.

Abstract

Rapid advances in next-generation sequencing technology are revolutionizing approaches to genomic and epigenomic studies of skin. Deep sequencing of cutaneous malignancies reveals heavily mutagenized genomes with large numbers of low-prevalence mutations and multiple resistance mechanisms to targeted therapies. Next-generation sequencing approaches have already paid rich dividends in identifying the genetic causes of dermatologic disease, both in heritable mutations and the somatic aberrations that underlie cutaneous mosaicism. Although epigenetic alterations clearly influence tumorigenesis, pluripotent stem cell biology, and epidermal cell lineage decisions, labor and cost-intensive approaches long delayed a genome-scale perspective. New insights into epigenomic mechanisms in skin disease should arise from the accelerating assessment of histone modification, DNA methylation, and related gene expression signatures.

Citing Articles

Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)--(2-hydroxyethyl)--Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms.

Song H, Hwang Y, Ha J, Boo Y Int J Mol Sci. 2020; 21(13).

PMID: 32605171 PMC: 7370187. DOI: 10.3390/ijms21134589.

Global and gene-specific DNA methylation and hydroxymethylation in human skin exposed and not exposed to sun radiation.

da Silva M, Melo A, Costa L, Barroso H, de Oliveira N An Bras Dermatol. 2018; 92(6):793-800.

PMID: 29364434 PMC: 5786392. DOI: 10.1590/abd1806-4841.20175875.

Advances and Applications of Ion Torrent Personal Genome Machine in Cutaneous Squamous Cell Carcinoma Reveal Novel Gene Mutations.

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Identification of a Novel Mutation of Gene in a Lybian Patient with Hereditary Epidermolysis Bullosa by Whole Exome Sequencing.

Laroussi N, Messaoud O, Chargui M, Ben Fayala C, Elahlafi A, Mokni M Ann Dermatol. 2017; 29(2):243-246.

PMID: 28392661 PMC: 5383759. DOI: 10.5021/ad.2017.29.2.243.

Genome-wide epigenetics.

Capell B, Berger S J Invest Dermatol. 2013; 133(6):e9.

PMID: 23673507 PMC: 4824393. DOI: 10.1038/jid.2013.173.

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