» Articles » PMID: 20686503

AML Xenograft Efficiency is Significantly Improved in NOD/SCID-IL2RG Mice Constitutively Expressing Human SCF, GM-CSF and IL-3

Overview
Journal Leukemia
Specialties Hematology
Oncology
Date 2010 Aug 6
PMID 20686503
Citations 233
Authors
Affiliations
Soon will be listed here.
Citing Articles

Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML.

Basova P, Minarik L, Magalhaes-Novais S, Balounova J, Zemanova Z, Aghova T Front Oncol. 2025; 14():1414950.

PMID: 39839764 PMC: 11747314. DOI: 10.3389/fonc.2024.1414950.


Immune Checkpoint Molecules as Biomarkers of Bone Infection and Clinical Outcome.

Saito M, McDonald K, Grier A, Grier A, Meghwani H, Rangel-Moreno J bioRxiv. 2025; .

PMID: 39803468 PMC: 11722373. DOI: 10.1101/2024.12.30.630837.


Myeloid Cell Mobilization and Recruitment by Human Mesothelioma in NSG-SGM3 Mice.

Shindyapin V, Gubernatorova E, Gorshkova E, Chicherina N, Sysonov F, Yakovleva A Cells. 2025; 13(24.

PMID: 39768223 PMC: 11675005. DOI: 10.3390/cells13242135.


Immune deficiency phenotypes of Il2rg, Rag2 or Il2rg/Rag2 double knockout rats; establishment of human leukemia xenograft models.

Kim J, Lim H, Kwon E, Mashimo T, Kang B Lab Anim Res. 2024; 40(1):43.

PMID: 39731164 PMC: 11673691. DOI: 10.1186/s42826-024-00231-5.


The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development.

Sturgeon C, Wagenblast E, Izzo F, Papapetrou E Blood Cancer Discov. 2024; 6(2):94-109.

PMID: 39652739 PMC: 11876951. DOI: 10.1158/2643-3230.BCD-24-0235.


References
1.
Nicolini F, Cashman J, Hogge D, Humphries R, Eaves C . NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia. 2003; 18(2):341-7. DOI: 10.1038/sj.leu.2403222. View

2.
Mulloy J, Cammenga J, Mackenzie K, Berguido F, Moore M, Nimer S . The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells. Blood. 2002; 99(1):15-23. DOI: 10.1182/blood.v99.1.15. View

3.
Shultz L, Ishikawa F, Greiner D . Humanized mice in translational biomedical research. Nat Rev Immunol. 2007; 7(2):118-30. DOI: 10.1038/nri2017. View

4.
Shultz L, Lyons B, Burzenski L, Gott B, Chen X, Chaleff S . Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol. 2005; 174(10):6477-89. DOI: 10.4049/jimmunol.174.10.6477. View

5.
Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K . NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002; 100(9):3175-82. DOI: 10.1182/blood-2001-12-0207. View