Arthroplasty in Veterans: Analysis of Cartilage, Bone, Serum, and Synovial Fluid Reveals Differences and Similarities in Osteoarthritis with and Without Comorbid Diabetes

Overview

Journal J Rehabil Res Dev

Specialties Biomedical Engineering
Rehabilitation Medicine

Date 2012 Jan 12

PMID 22234664

Citations 25

Authors

Trevor W Oren

Sergiu Botolin

Allison Williams

Allan Bucknell

Karen B King

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis patients with diabetes who receive total knee arthroplasty are more vulnerable to complications, including aseptic loosening and need for revision surgery. To elucidate mechanisms related to arthroplasty failure in diabetes, we examined serum and synovial fluid markers as well as collagen crosslinks in bone and cartilage of 20 patients (10 with diabetes, 10 controls without) undergoing this procedure. Hemoglobin A1c, body mass index, bone alkaline phosphatase, leptin, osteocalcin, and pyridinium were analyzed along with tissue content of the crosslinks hydroxylysylpyridinoline, lysylpyridinoline, and pentosidine. Pentosidine levels in tissue specimens from diabetic subjects were higher than in control subjects. Osteocalcin levels negatively correlated with hydroxylysylpyridinoline levels in cartilage. Osteocalcin levels also negatively correlated with pentosidine levels in cartilage, but only in subjects with diabetes. This study suggests potential metabolic mechanisms for arthroplasty failure in patients with diabetes.

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