Clinical Significance and Prognostic Value of PAX3 Expression in Human Glioma

Overview

Journal J Mol Neurosci

Specialties Molecular Biology
Neurology

Date 2012 Jan 11

PMID 22231626

Citations 9

Authors

Jian Chen

Liang Xia

Xiujie Wu

Liqin Xu

Dekang Nie

Jinlong Shi

Xide Xu

Lanchun Ni

Shaoqing Ju

Xinhua Wu

Hui Zhu

Wei Shi

Affiliations

Soon will be listed here.

Abstract

The paired box 3 (PAX3), a crucial transcription factor, is normally expressed during embryonic development and is absent in normal adult human tissues. Deregulated expression of PAX3 has been observed in tumors like rhabdomyosarcoma and melanomas. To assess deregulated PAX3 expression in patients with gliomas, these samples from 57 glioma patients (13 grade I, 16 grade II, 14 grade III, and 14 grade IV tumors) and 10 normal brain specimens acquired from 10 patients undergoing surgery for epilepsy as control were obtained. PAX3 expression was measured by RT-PCR, Western blot, and immunohistochemistry. Survival analyses were performed using the Kaplan-Meier method. Association between PAX3 expression, clinicopathological characteristics, and patients' survival were analyzed by using SPSS 17.0. We found that the expression of PAX3 was upregulated in high-grade glioma tissues compared with that in low-grade and normal brain tissues, and increased with ascending tumor World Health Organization (WHO) grades (P = 0.001). The increased PAX3 expression in gliomas was significantly associated with higher WHO grade (P = 0.021) and poorer disease-specific survival of patients (P = 0.001). Our results suggested that PAX3 might be an intrinsic regulator of progression in glioma cells and it might serve as a prognostic factor for this dismal disease.

Citing Articles

Emerging Pathogenic and Prognostic Significance of Paired Box 3 (PAX3) Protein in Adult Gliomas.

Angelopoulou E, Paudel Y, Piperi C Transl Oncol. 2019; 12(10):1357-1363.

PMID: 31352198 PMC: 6664158. DOI: 10.1016/j.tranon.2019.07.001.

Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) overexpression is associated with poor prognosis in patients with cervical cancer.

Chay D, Han G, Nam S, Cho H, Chung J, Hewitt S Int J Clin Oncol. 2019; 24(11):1429-1439.

PMID: 31302815 PMC: 8183735. DOI: 10.1007/s10147-019-01507-w.

PAX3 Promotes Proliferation of Human Glioma Cells by WNT/β-Catenin Signaling Pathways.

Liang X, Dong Z, Bin W, Dekang N, Xuhang Z, Shuyuan Z J Mol Neurosci. 2019; 68(1):66-77.

PMID: 30826985 DOI: 10.1007/s12031-019-01283-2.

MicroRNA-485-5p attenuates cell proliferation in glioma by directly targeting paired box 3.

Wang R, Zuo X, Wang K, Han Q, Zuo J, Ni H Am J Cancer Res. 2019; 8(12):2507-2517.

PMID: 30662807 PMC: 6325470.

MiR-1 Suppresses Proliferation of Osteosarcoma Cells by Up-regulating p21 PAX3.

Fujii R, Osaka E, Sato K, Tokuhashi Y Cancer Genomics Proteomics. 2018; 16(1):71-79.

PMID: 30587501 PMC: 6348397. DOI: 10.21873/cgp.20113.

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