A PANorama of PAX Genes in Cancer and Development

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2006 Jan 7

PMID 16397527

Citations 119

Authors

Ewan J D Robson

Shu-Jie He

Michael R Eccles

Affiliations

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Abstract

Populations of self-renewing cells that arise during normal embryonic development harbour the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour generation. So, control mechanisms are essential to prevent rapidly expanding populations from malignant growth. Transcription factors have crucial roles in ensuring establishment of such regulation, with the Pax gene family prominent amongst these. This review examines the role of Pax family members during embryogenesis, and their contribution to tumorigenesis when subverted.

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