Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection

Overview

Journal J Acquir Immune Defic Syndr

Specialty Infectious Diseases

Date 2012 Jan 10

PMID 22227487

Citations 40

Authors

Alessandra Pontillo

Telma M Oshiro

Martina Girardelli

Anselmo J Kamada

Sergio Crovella

Alberto J S Duarte

Affiliations

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Abstract

The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.

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