Behavior of Seeds and Soil in the Mechanism of Metastasis: a Deeper Understanding

Overview

Journal Cancer Sci

Specialty Oncology

Date 2012 Jan 4

PMID 22212856

Citations 43

Authors

Lucy Mathot

Johan Stenninger

Affiliations

Soon will be listed here.

Abstract

The so-called "seed and soil" hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to "selected" sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy?

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