Influence of Patient-related Variables on Clozapine Plasma Levels

Overview

Journal Am J Psychiatry

Specialty Psychiatry

Date 1990 Nov 1

PMID 2221158

Citations 23

Authors

C Haring

W W Fleischhacker

P Schett

C Humpel

C Barnas

A Saria

Affiliations

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Abstract

The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis.

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