Cocaine-taking and Cocaine-seeking Behaviors in Rats Remain Stable After Systemic Administration of GYKI 52466: a Non-competitive AMPA Receptor Antagonist

Overview

Journal Neurosci Lett

Specialty Neurology

Date 2011 Dec 31

PMID 22206835

Citations 1

Authors

Ratika Srivastava

Zheng-Xiong Xi

Eliot L Gardner

Affiliations

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Abstract

Given the posited role of enhanced AMPA-mediated synaptic transmission in relapse to drug seeking, we investigated whether systemic administration of the AMPA receptor antagonist GYKI 52466 inhibits cocaine-taking and cocaine-seeking behavior in rats. Rats were trained to self-administer cocaine until stable self-administration was achieved. Effects of GYKI 52466 (1, 3, or 10mg/kg, i.v.) on cocaine self-administration were assessed. Animals were allowed to re-establish stable cocaine self-administration and were then behaviorally extinguished from drug taking. The effects of GYKI 52466 (3, 10mg/kg, i.v.) on cocaine-induced reinstatement of drug-seeking behavior were assessed. We found that GYKI 52466 failed to inhibit cocaine-taking and cocaine-seeking in both the self-administration and reinstatement paradigms. We suggest that although AMPA receptors may be involved in cocaine reward and addiction, the AMPA receptor antagonist GYKI 52466 has low therapeutic potential for cocaine addiction treatment.

Citing Articles

Role of cues and contexts on drug-seeking behaviour.

Perry C, Zbukvic I, Kim J, Lawrence A Br J Pharmacol. 2014; 171(20):4636-72.

PMID: 24749941 PMC: 4209936. DOI: 10.1111/bph.12735.

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