Different Neural Substrates Mediate Cocaine Seeking After Abstinence Versus Extinction Training: a Critical Role for the Dorsolateral Caudate-putamen

Overview

Journal J Neurosci

Specialty Neurology

Date 2006 Mar 31

PMID 16571766

Citations 186

Authors

Rita A Fuchs

R Kyle Branham

Ronald E See

Affiliations

Soon will be listed here.

Abstract

Cue-induced reinstatement of extinguished drug seeking is a preclinical model of relapse. However, relapse typically occurs after abstinence rather than explicit extinction training. We show that inactivation of the dorsolateral caudate-putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence. This suggests that there is limited overlap in the substrates of cocaine seeking after abstinence versus extinction, and that habit learning exerts greater control over drug seeking than regions implicated in stimulus-reward associations.

Citing Articles

Delineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains.

Leonard M, Miczek K, Covington 3rd H Psychopharmacology (Berl). 2024; 242(3):593-615.

PMID: 39511030 DOI: 10.1007/s00213-024-06711-9.

Orbitofrontal cortex to dorsal striatum circuit is critical for incubation of oxycodone craving after forced abstinence.

Lin H, Olaniran A, Luo X, Strauch J, Burke M, Matheson C Addict Biol. 2024; 29(10):e13440.

PMID: 39380299 PMC: 11461755. DOI: 10.1111/adb.13440.

Role of dorsal striatum circuits in relapse to opioid seeking after voluntary abstinence.

Ma Z, Duan Y, Fredriksson I, Tsai P, Batista A, Lu H Neuropsychopharmacology. 2024; 50(2):452-460.

PMID: 39300270 PMC: 11632082. DOI: 10.1038/s41386-024-01990-4.

Astrocyte Ca in the dorsal striatum suppresses neuronal activity to oppose cue-induced reinstatement of cocaine seeking.

Tavakoli N, Malone S, Anderson T, Neeley R, Asadipooya A, Bardo M Front Cell Neurosci. 2024; 18:1347491.

PMID: 39280793 PMC: 11393831. DOI: 10.3389/fncel.2024.1347491.

Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues.

Ndiaye N, Shamleh S, Casale D, Castaneda-Ouellet S, Laplante I, Robinson M Psychopharmacology (Berl). 2024; 241(10):2015-2032.

PMID: 38767684 DOI: 10.1007/s00213-024-06614-9.

References

Fuchs R, Coffey G, Baker D, ODell L, Neisewander J . Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. Neuropsychopharmacology. 1998; 19(1):48-59. DOI: 10.1016/S0893-133X(97)00205-4. View

Fuchs R, Evans K, Parker M, See R . Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl). 2004; 176(3-4):459-65. DOI: 10.1007/s00213-004-1895-6. View

Fuchs R, Evans K, Ledford C, Parker M, Case J, Mehta R . The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats. Neuropsychopharmacology. 2004; 30(2):296-309. DOI: 10.1038/sj.npp.1300579. View

Jog M, Kubota Y, Connolly C, Hillegaart V, Graybiel A . Building neural representations of habits. Science. 1999; 286(5445):1745-9. DOI: 10.1126/science.286.5445.1745. View

Garavan H, Pankiewicz J, Bloom A, Cho J, Sperry L, Ross T . Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Am J Psychiatry. 2000; 157(11):1789-98. DOI: 10.1176/appi.ajp.157.11.1789. View

Grimm J, Hope B, Wise R, Shaham Y . Neuroadaptation. Incubation of cocaine craving after withdrawal. Nature. 2001; 412(6843):141-2. PMC: 2889613. DOI: 10.1038/35084134. View

McFarland K, Kalivas P . The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J Neurosci. 2001; 21(21):8655-63. PMC: 6762812. View

Shalev U, Grimm J, Shaham Y . Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol Rev. 2002; 54(1):1-42. DOI: 10.1124/pr.54.1.1. View

Ito R, Dalley J, Robbins T, Everitt B . Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue. J Neurosci. 2002; 22(14):6247-53. PMC: 6757945. DOI: 20026606. View

10.

Sutton M, Schmidt E, Choi K, Schad C, Whisler K, Simmons D . Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature. 2003; 421(6918):70-5. DOI: 10.1038/nature01249. View

11.

Gerdeman G, Partridge J, Lupica C, Lovinger D . It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends Neurosci. 2003; 26(4):184-92. DOI: 10.1016/S0166-2236(03)00065-1. View

12.

McLaughlin J, See R . Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2003; 168(1-2):57-65. DOI: 10.1007/s00213-002-1196-x. View

13.

McFarland K, Davidge S, Lapish C, Kalivas P . Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neurosci. 2004; 24(7):1551-60. PMC: 6730472. DOI: 10.1523/JNEUROSCI.4177-03.2004. View

14.

Porrino L, Daunais J, Smith H, Nader M . The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration. Neurosci Biobehav Rev. 2004; 27(8):813-20. DOI: 10.1016/j.neubiorev.2003.11.013. View

15.

Fuchs R, Evans K, Parker M, See R . Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats. J Neurosci. 2004; 24(29):6600-10. PMC: 6729870. DOI: 10.1523/JNEUROSCI.1924-04.2004. View

16.

Self D, Choi K, Simmons D, Walker J, Smagula C . Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration. Learn Mem. 2004; 11(5):648-57. PMC: 523085. DOI: 10.1101/lm.81404. View

17.

OBrien C, Childress A, Ehrman R, Robbins S . Conditioning factors in drug abuse: can they explain compulsion?. J Psychopharmacol. 1998; 12(1):15-22. DOI: 10.1177/026988119801200103. View