The Paracoccidioides Cell Wall: Past and Present Layers Toward Understanding Interaction with the Host

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2011 Dec 24

PMID 22194733

Citations 39

Authors

Rosana Puccia

Milene Carmes Vallejo

Alisson Leonardo Matsuo

Larissa Valle Guilhen Longo

Affiliations

Soon will be listed here.

Abstract

The cell wall of pathogenic fungi plays import roles in the interaction with the host, so that its composition and structure may determine the course of infection. Here we present an overview of the current and past knowledge on the cell wall constituents of Paracoccidioides brasiliensis and P. lutzii. These are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis, a systemic granulomatous, and debilitating disease. Focus is given on cell wall carbohydrate and protein contents, their immune-stimulatory features, adhesion properties, drug target characteristics, and morphological phase specificity. We offer a journey toward the future understanding of the dynamic nature of the cell wall and of the changes that may occur when the fungus infects the human host.

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References

Rodrigues M, Travassos L, Miranda K, Franzen A, Rozental S, De Souza W . Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth. Infect Immun. 2000; 68(12):7049-60. PMC: 97815. DOI: 10.1128/IAI.68.12.7049-7060.2000. View

Ganiko L, Puccia R, Mariano V, SantAnna O, Freymuller E, Roque-Barreira M . Paracoccin, an N-acetyl-glucosamine-binding lectin of Paracoccidioides brasiliensis, is involved in fungal growth. Microbes Infect. 2007; 9(6):695-703. DOI: 10.1016/j.micinf.2007.02.012. View

Taborda C, Juliano M, Puccia R, Franco M, Travassos L . Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB/c mice. Infect Immun. 1998; 66(2):786-93. PMC: 107971. DOI: 10.1128/IAI.66.2.786-793.1998. View

Brummer E, Restrepo A, Hanson L, Stevens D . Virulence of Paracoccidiodes brasiliensis: the influence of in vitro passage and storage. Mycopathologia. 1990; 109(1):13-7. DOI: 10.1007/BF00437001. View

Tacco B, Parente J, Barbosa M, Bao S, Gsoes T, Pereira M . Characterization of a secreted aspartyl protease of the fungal pathogen Paracoccidioides brasiliensis. Med Mycol. 2009; 47(8):845-54. DOI: 10.3109/13693780802695512. View

Rodrigues M, Nimrichter L, Oliveira D, Frases S, Miranda K, Zaragoza O . Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport. Eukaryot Cell. 2006; 6(1):48-59. PMC: 1800364. DOI: 10.1128/EC.00318-06. View

Straus A, Freymuller E, Travassos L, Takahashi H . Immunochemical and subcellular localization of the 43 kDa glycoprotein antigen of Paracoccidioides brasiliensis with monoclonal antibodies. J Med Vet Mycol. 1996; 34(3):181-6. DOI: 10.1080/02681219680000301. View

Bailao A, Schrank A, Borges C, Dutra V, Walquiria Ines Molinari-Madlum E, Felipe M . Differential gene expression by Paracoccidioides brasiliensis in host interaction conditions: representational difference analysis identifies candidate genes associated with fungal pathogenesis. Microbes Infect. 2006; 8(12-13):2686-97. DOI: 10.1016/j.micinf.2006.07.019. View

San-Blas G, San-Blas F, Ormaechea E, Serrano L . Cell wall analysis of an adenine-requiring mutant of the yeast-like form of Paracoccidioides brasiliensis strain IVIC Pb9. Sabouraudia. 1977; 15(3):297-303. DOI: 10.1080/00362177785380121. View

10.

Albuquerque P, Nakayasu E, Rodrigues M, Frases S, Casadevall A, Zancope-Oliveira R . Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes. Cell Microbiol. 2008; 10(8):1695-710. PMC: 2562661. DOI: 10.1111/j.1462-5822.2008.01160.x. View

11.

Nino-Vega G, Munro C, San-Blas G, Gooday G, Gow N . Differential expression of chitin synthase genes during temperature-induced dimorphic transitions in Paracoccidioides brasiliensis. Med Mycol. 2000; 38(1):31-9. DOI: 10.1080/mmy.38.1.31.39. View

12.

KANETSUNA F, CARBONELL L, MORENO R, Rodriguez J . Cell wall composition of the yeast and mycelial forms of Paracoccidioides brasiliensis. J Bacteriol. 1969; 97(3):1036-41. PMC: 249811. DOI: 10.1128/jb.97.3.1036-1041.1969. View

13.

Vicentini A, Gesztesi J, Franco M, De Souza W, de Moraes J, Travassos L . Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis. Infect Immun. 1994; 62(4):1465-9. PMC: 186304. DOI: 10.1128/iai.62.4.1465-1469.1994. View

14.

San-Blas F . Ultrastructure of spore formation in Paracoccidioides brasiliensis. J Med Vet Mycol. 1986; 24(3):203-10. View

15.

Anjos A, Calvi S, Ferracini R, Peracoli M, Silva C, Soares A . Role of Paracoccidioides brasiliensis cell wall fraction containing beta-glucan in tumor necrosis factor-alpha production by human monocytes: correlation with fungicidal activity. Med Mycol. 2002; 40(4):377-82. DOI: 10.1080/mmy.40.4.377.382. View

16.

San-Blas G, Prieto A, Bernabe M, Ahrazem O, Moreno B, Leal J . alpha-galf I -->6-alpha-mannopyranoside side chains in Paracoccidioides brasiliensis cell wall are shared by members of the Onygenales, but not by galactomannans of other fungal genera. Med Mycol. 2005; 43(2):153-9. DOI: 10.1080/13693780410001731556. View

17.

Takahashi H, Toledo M, Suzuki E, Tagliari L, Straus A . Current relevance of fungal and trypanosomatid glycolipids and sphingolipids: studies defining structures conspicuously absent in mammals. An Acad Bras Cienc. 2009; 81(3):477-88. DOI: 10.1590/s0001-37652009000300012. View

18.

San-Blas G, San-Blas F, Serrano L . Host-parasite relationships in the yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9. Infect Immun. 1977; 15(2):343-6. PMC: 421372. DOI: 10.1128/iai.15.2.343-346.1977. View

19.

Sorais F, Barreto L, Leal J, Bernabe M, San-Blas G, Nino-Vega G . Cell wall glucan synthases and GTPases in Paracoccidioides brasiliensis. Med Mycol. 2009; 48(1):35-47. DOI: 10.3109/13693780802713356. View

20.

da Silva M, Marques A, Nosanchuk J, Casadevall A, Travassos L, Taborda C . Melanin in the dimorphic fungal pathogen Paracoccidioides brasiliensis: effects on phagocytosis, intracellular resistance and drug susceptibility. Microbes Infect. 2005; 8(1):197-205. DOI: 10.1016/j.micinf.2005.06.018. View