Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2011 Dec 23

PMID 22190724

Citations 32

Authors

Jason D Graci

Nina F Gnadig

Jessica E Galarraga

Christian Castro

Marco Vignuzzi

Craig E Cameron

Affiliations

Soon will be listed here.

Abstract

The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis.

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