Modulating Pain in the Periphery: Gene-based Therapies to Enhance Peripheral Opioid Analgesia: Bonica Lecture, ASRA 2010

Overview

Journal Reg Anesth Pain Med

Date 2011 Dec 23

PMID 22189620

Citations 4

Authors

Srinivasa N Raja

Affiliations

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Abstract

This article provides a brief overview of earlier work of our group on the peripheral signaling of pain, summarizes more recent studies on the role of opioids in chronic neuropathic pain, and speculates on the future of gene-based therapies as novel strategies to enhance the peripheral modulation of pain. Neurophysiologic and psychophysical studies have revealed features of primary afferent activity from somatic tissue that led to improved understanding of the physiology and pathophysiology of pain signaling by nociceptive and nonnociceptive fibers. The demonstration of peripheral opioid mechanisms in neuropathic pain suggests a potential role for these receptors in the modulation of pain at its initiation site. Our work has focused on characterizing this peripheral opioid analgesia in chronic neuropathic pain such that it can be exploited to develop novel and potent peripheral analgesics for its treatment. Ongoing research on virus-mediated gene transfer strategies to enhance peripheral opioid analgesia is presented.

Citing Articles

[Pain inhibition by opioids-new concepts].

Stein C Schmerz. 2019; 33(4):295-302.

PMID: 31222410 DOI: 10.1007/s00482-019-0386-y.

[Pain inhibition by opioids-new concepts].

Stein C Anaesthesist. 2019; 68(2):97-103.

PMID: 30645691 DOI: 10.1007/s00101-018-0528-0.

Peripheral interactions between cannabinoid and opioid receptor agonists in a model of inflammatory mechanical hyperalgesia.

Auh Q, Chun Y, Melemedjian O, Zhang Y, Ro J Brain Res Bull. 2016; 125:211-7.

PMID: 27450703 PMC: 7909681. DOI: 10.1016/j.brainresbull.2016.07.009.

Targeting pain and inflammation by peripherally acting opioids.

Stein C Front Pharmacol. 2013; 4:123.

PMID: 24068999 PMC: 3779927. DOI: 10.3389/fphar.2013.00123.

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