Targeting Pain and Inflammation by Peripherally Acting Opioids

Overview

Journal Front Pharmacol

Date 2013 Sep 27

PMID 24068999

Citations 28

Authors

Christoph Stein

Affiliations

Soon will be listed here.

Citing Articles

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References

Dahan A, van Dorp E, Smith T, Yassen A . Morphine-6-glucuronide (M6G) for postoperative pain relief. Eur J Pain. 2007; 12(4):403-11. DOI: 10.1016/j.ejpain.2007.07.009. View

Vadivelu N, Mitra S, Hines R . Peripheral opioid receptor agonists for analgesia: a comprehensive review. J Opioid Manag. 2011; 7(1):55-68. DOI: 10.5055/jom.2011.0049. View

Zollner C, Mousa S, Fischer O, Rittner H, Shaqura M, Brack A . Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest. 2008; 118(3):1065-73. PMC: 2214843. DOI: 10.1172/JCI25911. View

Picard P, Tramer M, McQuay H, Moore R . Analgesic efficacy of peripheral opioids (all except intra-articular): a qualitative systematic review of randomised controlled trials. Pain. 1997; 72(3):309-18. DOI: 10.1016/s0304-3959(97)00040-7. View

Binning A, Przesmycki K, Sowinski P, Morrison L, Smith T, Marcus P . A randomised controlled trial on the efficacy and side-effect profile (nausea/vomiting/sedation) of morphine-6-glucuronide versus morphine for post-operative pain relief after major abdominal surgery. Eur J Pain. 2010; 15(4):402-8. DOI: 10.1016/j.ejpain.2010.09.007. View

Patwardhan A, Berg K, Akopain A, Jeske N, Gamper N, Clarke W . Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors. J Neurosci. 2005; 25(39):8825-32. PMC: 6725594. DOI: 10.1523/JNEUROSCI.0160-05.2005. View

Stein C . Peripheral mechanisms of opioid analgesia. Anesth Analg. 1993; 76(1):182-91. DOI: 10.1213/00000539-199301000-00031. View

Farley P . Should topical opioid analgesics be regarded as effective and safe when applied to chronic cutaneous lesions?. J Pharm Pharmacol. 2011; 63(6):747-56. DOI: 10.1111/j.2042-7158.2011.01252.x. View

Roques B, Fournie-Zaluski M, Wurm M . Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain. Nat Rev Drug Discov. 2012; 11(4):292-310. DOI: 10.1038/nrd3673. View

10.

Vetter I, Cheng W, Peiris M, Wyse B, Roberts-Thomson S, Zheng J . Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. J Biol Chem. 2008; 283(28):19540-50. PMC: 2443658. DOI: 10.1074/jbc.M707865200. View

11.

Stein C, Schafer M, Machelska H . Attacking pain at its source: new perspectives on opioids. Nat Med. 2003; 9(8):1003-8. DOI: 10.1038/nm908. View

12.

Stein C, Machelska H . Modulation of peripheral sensory neurons by the immune system: implications for pain therapy. Pharmacol Rev. 2011; 63(4):860-81. DOI: 10.1124/pr.110.003145. View

13.

Rittner H, Hackel D, Voigt P, Mousa S, Stolz A, Labuz D . Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. PLoS Pathog. 2009; 5(4):e1000362. PMC: 2657213. DOI: 10.1371/journal.ppat.1000362. View

14.

Busch-Dienstfertig M, Labuz D, Wolfram T, Vogel N, Stein C . JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats. Mol Pain. 2012; 8:83. PMC: 3544692. DOI: 10.1186/1744-8069-8-83. View

15.

Stein C, Kuchler S . Non-analgesic effects of opioids: peripheral opioid effects on inflammation and wound healing. Curr Pharm Des. 2012; 18(37):6053-69. DOI: 10.2174/138161212803582513. View

16.

Stein C . Towards safer and more effective analgesia. Vet J. 2012; 196(1):6-7. DOI: 10.1016/j.tvjl.2012.09.013. View

17.

Kalso E, Smith L, McQuay H, Moore A . No pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphine. Pain. 2002; 98(3):269-275. DOI: 10.1016/S0304-3959(02)00019-2. View

18.

Schreiter A, Gore C, Labuz D, Fournie-Zaluski M, Roques B, Stein C . Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. FASEB J. 2012; 26(12):5161-71. DOI: 10.1096/fj.12-208678. View

19.

Cayla C, Labuz D, Machelska H, Bader M, Schafer M, Stein C . Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptors. Anesthesiology. 2012; 116(2):448-57. DOI: 10.1097/ALN.0b013e318242b2ea. View

20.

Labuz D, Schmidt Y, Schreiter A, Rittner H, Mousa S, Machelska H . Immune cell-derived opioids protect against neuropathic pain in mice. J Clin Invest. 2009; 119(2):278-86. PMC: 2631295. DOI: 10.1172/JCI36246. View