Matrix Proteases in Mitochondrial DNA Function

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2011 Dec 17

PMID 22172992

Citations 33

Authors

Yuichi Matsushima

Laurie S Kaguni

Affiliations

Soon will be listed here.

Abstract

Lon, ClpXP and m-AAA are the three major ATP-dependent proteases in the mitochondrial matrix. All three are involved in general quality control by degrading damaged or abnormal proteins. In addition to this role, they are proposed to serve roles in mitochondrial DNA functions including packaging and stability, replication, transcription and translation. In particular, Lon has been implicated in mtDNA metabolism in yeast, fly and humans. Here, we review the role of Lon protease in mitochondrial DNA functions, and discuss a putative physiological role for mitochondrial transcription factor A (TFAM) degradation by Lon protease. We also discuss the possible roles of m-AAA and ClpXP in mitochondrial DNA functions, and the putative candidate substrates for the three matrix proteases. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.

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