The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2021 Mar 8

PMID 33680284

Citations 5

Authors

Jinlin Liu

Li Zhong

Rui Guo

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) is the leading cause of death in the world. The mechanism behind CVDs has been studied for decades; however, the pathogenesis is still controversial. Mitochondrial homeostasis plays an essential role in maintaining the normal function of the cardiovascular system. The alterations of any protein function in mitochondria may induce abnormal mitochondrial quality control and unexpected mitochondrial dysfunction, leading to CVDs. Posttranslational modifications (PTMs) affect protein function by reversibly changing their conformation. This review summarizes how common and novel PTMs influence the development of CVDs by regulating mitochondrial quality control. It provides not only ideas for future research on the mechanism of some types of CVDs but also ideas for CVD treatments with therapeutic potential.

Citing Articles

Retracted: The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases.

Longevity O Oxid Med Cell Longev. 2023; 2023:9821720.

PMID: 37868730 PMC: 10586338. DOI: 10.1155/2023/9821720.

Changes of ubiquitylated proteins in atrial fibrillation associated with heart valve disease: proteomics in human left atrial appendage tissue.

Wu C, Teng S, Bai F, Liao X, Zhou X, Liu Q Front Cardiovasc Med. 2023; 10:1198486.

PMID: 37701139 PMC: 10493305. DOI: 10.3389/fcvm.2023.1198486.

Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases.

Xue Q, Yang Y, Li H, Li X, Zou L, Li T Genes Dis. 2023; 10(6):2479-2490.

PMID: 37554202 PMC: 10404885. DOI: 10.1016/j.gendis.2022.10.025.

The Functional Roles of ISG15/ISGylation in Cancer.

Yuan Y, Qin H, Li H, Shi W, Bao L, Xu S Molecules. 2023; 28(3).

PMID: 36771004 PMC: 9918931. DOI: 10.3390/molecules28031337.

Mitochondrial Proteins as Source of Cancer Neoantigens.

Prota G, Lechuga-Vieco A, De Libero G Int J Mol Sci. 2022; 23(5).

PMID: 35269772 PMC: 8909979. DOI: 10.3390/ijms23052627.

References

Park J, Chen Y, Tishkoff D, Peng C, Tan M, Dai L . SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013; 50(6):919-30. PMC: 3769971. DOI: 10.1016/j.molcel.2013.06.001. View

Sundaresan N, Pillai V, Wolfgeher D, Samant S, Vasudevan P, Parekh V . The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal. 2011; 4(182):ra46. DOI: 10.1126/scisignal.2001465. View

Gao L, Zhao Y, He J, Yan Y, Xu L, Lin N . The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury. J Genet Genomics. 2018; 45(3):125-135. DOI: 10.1016/j.jgg.2017.12.002. View

Wan J, Liu H, Chu J, Zhang H . Functions and mechanisms of lysine crotonylation. J Cell Mol Med. 2019; 23(11):7163-7169. PMC: 6815811. DOI: 10.1111/jcmm.14650. View

Sun T, Ding W, Xu T, Ao X, Yu T, Li M . Parkin Regulates Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury by Targeting Cyclophilin-D. Antioxid Redox Signal. 2019; 31(16):1177-1193. DOI: 10.1089/ars.2019.7734. View

Fu H, Tian C, Ye X, Sheng X, Wang H, Liu Y . Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells. Stem Cell Reports. 2018; 11(1):70-87. PMC: 6066961. DOI: 10.1016/j.stemcr.2018.05.003. View

Tan M, Peng C, Anderson K, Chhoy P, Xie Z, Dai L . Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014; 19(4):605-17. PMC: 4108075. DOI: 10.1016/j.cmet.2014.03.014. View

Miki T, Itoh T, Sunaga D, Miura T . Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning. Cardiovasc Diabetol. 2012; 11:67. PMC: 3461466. DOI: 10.1186/1475-2840-11-67. View

Wang J, Jiao J, Li Q, Long B, Wang K, Liu J . miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med. 2010; 17(1):71-8. DOI: 10.1038/nm.2282. View

10.

Gareau J, Lima C . The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol. 2010; 11(12):861-71. PMC: 3079294. DOI: 10.1038/nrm3011. View

11.

Lemasters J . Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biol. 2014; 2:749-54. PMC: 4085350. DOI: 10.1016/j.redox.2014.06.004. View

12.

van Dierendonck X, Sancerni T, Alves-Guerra M, Stienstra R . The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance. J Biol Chem. 2021; 295(51):17535-17548. PMC: 7762953. DOI: 10.1074/jbc.RA120.014868. View

13.

Hofer A, Wenz T . Post-translational modification of mitochondria as a novel mode of regulation. Exp Gerontol. 2014; 56:202-20. DOI: 10.1016/j.exger.2014.03.006. View

14.

Liu X, Wei W, Liu Y, Yang X, Wu J, Zhang Y . MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300. Cell Discov. 2017; 3:17016. PMC: 5441097. DOI: 10.1038/celldisc.2017.16. View

15.

Liberti M, Locasale J . Histone Lactylation: A New Role for Glucose Metabolism. Trends Biochem Sci. 2020; 45(3):179-182. DOI: 10.1016/j.tibs.2019.12.004. View

16.

Truban D, Hou X, Caulfield T, Fiesel F, Springer W . PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?. J Parkinsons Dis. 2016; 7(1):13-29. PMC: 5302033. DOI: 10.3233/JPD-160989. View

17.

Hershberger K, Abraham D, Liu J, Locasale J, Grimsrud P, Hirschey M . Ablation of in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. J Biol Chem. 2018; 293(27):10630-10645. PMC: 6036188. DOI: 10.1074/jbc.RA118.002187. View

18.

Chouchani E, Pell V, Gaude E, Aksentijevic D, Sundier S, Robb E . Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014; 515(7527):431-435. PMC: 4255242. DOI: 10.1038/nature13909. View

19.

Youle R, Narendra D . Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2010; 12(1):9-14. PMC: 4780047. DOI: 10.1038/nrm3028. View

20.

Bugger H, Schwarzer M, Chen D, Schrepper A, Amorim P, Schoepe M . Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure. Cardiovasc Res. 2009; 85(2):376-84. DOI: 10.1093/cvr/cvp344. View