A System for Recording Neural Activity Chronically and Simultaneously from Multiple Cortical and Subcortical Regions in Nonhuman Primates

Overview

Journal J Neurophysiol

Publisher American Physiological Society

Specialties Neurology
Physiology

Date 2011 Dec 16

PMID 22170970

Citations 26

Authors

Joseph Feingold

Theresa M Desrochers

Naotaka Fujii

Ray Harlan

Patrick L Tierney

Hideki Shimazu

Ken-Ichi Amemori

Ann M Graybiel

Affiliations

Soon will be listed here.

Abstract

A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system that allows the independent movement of hundreds of electrodes chronically implanted in several cortical and subcortical structures. We have tested this system in macaque monkeys, recording simultaneously from up to 127 electrodes in 14 brain regions for up to one year at a time. A key advantage of the system is that it can be used to sample different combinations of sites over prolonged periods, generating multiple snapshots of network activity from a single implant. Used in conjunction with microstimulation and injection methods, this versatile system represents a powerful tool for studying neural network activity in the primate brain.

Citing Articles

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References

Baker S, Philbin N, Spinks R, Pinches E, Wolpert D, MacManus D . Multiple single unit recording in the cortex of monkeys using independently moveable microelectrodes. J Neurosci Methods. 2000; 94(1):5-17. DOI: 10.1016/s0165-0270(99)00121-1. View

Graybiel A, Rauch S . Toward a neurobiology of obsessive-compulsive disorder. Neuron. 2001; 28(2):343-7. DOI: 10.1016/s0896-6273(00)00113-6. View

Jackson A, Fetz E . Compact movable microwire array for long-term chronic unit recording in cerebral cortex of primates. J Neurophysiol. 2007; 98(5):3109-18. DOI: 10.1152/jn.00569.2007. View

Chhatbar P, Kraus L, Semework M, Francis J . A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays. J Neurosci Methods. 2010; 188(2):187-94. DOI: 10.1016/j.jneumeth.2010.02.006. View

Otto K, Johnson M, Kipke D . Voltage pulses change neural interface properties and improve unit recordings with chronically implanted microelectrodes. IEEE Trans Biomed Eng. 2006; 53(2):333-40. DOI: 10.1109/TBME.2005.862530. View

Strick P, PRESTON J . Two representations of the hand in area 4 of a primate. I. Motor output organization. J Neurophysiol. 1982; 48(1):139-49. DOI: 10.1152/jn.1982.48.1.139. View

Galashan F, Rempel H, Meyer A, Gruber-Dujardin E, Kreiter A, Wegener D . A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys. J Neurophysiol. 2011; 105(6):3092-105. DOI: 10.1152/jn.00508.2010. View

Courtemanche R, Fujii N, Graybiel A . Synchronous, focally modulated beta-band oscillations characterize local field potential activity in the striatum of awake behaving monkeys. J Neurosci. 2003; 23(37):11741-52. PMC: 6740936. View

Nichols A, Ruffner T, Sommer M, WURTZ R . A screw microdrive for adjustable chronic unit recording in monkeys. J Neurosci Methods. 1998; 81(1-2):185-8. DOI: 10.1016/s0165-0270(98)00036-3. View

10.

Contreras D, Destexhe A, Sejnowski T, Steriade M . Control of spatiotemporal coherence of a thalamic oscillation by corticothalamic feedback. Science. 1996; 274(5288):771-4. DOI: 10.1126/science.274.5288.771. View

11.

Evarts E . Relation of pyramidal tract activity to force exerted during voluntary movement. J Neurophysiol. 1968; 31(1):14-27. DOI: 10.1152/jn.1968.31.1.14. View

12.

Fujii N, Hihara S, Iriki A . Dynamic social adaptation of motion-related neurons in primate parietal cortex. PLoS One. 2007; 2(4):e397. PMC: 1851098. DOI: 10.1371/journal.pone.0000397. View

13.

Hernandez A, Nacher V, Luna R, Alvarez M, Zainos A, Cordero S . Procedure for recording the simultaneous activity of single neurons distributed across cortical areas during sensory discrimination. Proc Natl Acad Sci U S A. 2008; 105(43):16785-90. PMC: 2571910. DOI: 10.1073/pnas.0808702105. View

14.

McCreery D, Lossinsky A, Pikov V, Liu X . Microelectrode array for chronic deep-brain microstimulation and recording. IEEE Trans Biomed Eng. 2006; 53(4):726-37. DOI: 10.1109/TBME.2006.870215. View

15.

Ecker A, Berens P, Keliris G, Bethge M, Logothetis N, Tolias A . Decorrelated neuronal firing in cortical microcircuits. Science. 2010; 327(5965):584-7. DOI: 10.1126/science.1179867. View

16.

Vetter R, Williams J, Hetke J, Nunamaker E, Kipke D . Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex. IEEE Trans Biomed Eng. 2004; 51(6):896-904. DOI: 10.1109/TBME.2004.826680. View

17.

Lei Y, Sun N, Wilson F, Wang X, Chen N, Yang J . Telemetric recordings of single neuron activity and visual scenes in monkeys walking in an open field. J Neurosci Methods. 2004; 135(1-2):35-41. DOI: 10.1016/j.jneumeth.2003.11.014. View

18.

Pasupathy A, Miller E . Different time courses of learning-related activity in the prefrontal cortex and striatum. Nature. 2005; 433(7028):873-6. DOI: 10.1038/nature03287. View

19.

Sommer M, Wurtz R . Brain circuits for the internal monitoring of movements. Annu Rev Neurosci. 2008; 31:317-38. PMC: 2813694. DOI: 10.1146/annurev.neuro.31.060407.125627. View

20.

Hochberg L, Serruya M, Friehs G, Mukand J, Saleh M, Caplan A . Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature. 2006; 442(7099):164-71. DOI: 10.1038/nature04970. View