Effects of Rose Hip Intake on Risk Markers of Type 2 Diabetes and Cardiovascular Disease: a Randomized, Double-blind, Cross-over Investigation in Obese Persons

Overview

Journal Eur J Clin Nutr

Specialty Nutritional Sciences

Date 2011 Dec 15

PMID 22166897

Citations 11

Authors

U Andersson

K Berger

A Hogberg

M Landin-Olsson

C Holm

Affiliations

Soon will be listed here.

Abstract

Background/objectives: In studies performed in mice, rose hip powder has been shown to both prevent and reverse high-fat diet-induced obesity and glucose intolerance as well as reduce plasma levels of cholesterol. The aim of this study was to investigate whether daily intake of rose hip powder over 6 weeks exerts beneficial metabolic effects in obese individuals.

Subjects/methods: A total of 31 obese individuals with normal or impaired glucose tolerance were enrolled in a randomized, double-blind, cross-over study in which metabolic effects of daily intake of a rose hip powder drink over 6 weeks was compared with a control drink. Body weight, glucose tolerance, blood pressure, blood lipids and markers of inflammation were assessed in the subjects.

Results: In comparison with the control drink, 6 weeks of daily consumption of the rose hip drink resulted in a significant reduction of systolic blood pressure (-3.4%; P=0.021), total plasma cholesterol (-4.9%; P=0.0018), low-density lipoprotein (LDL) cholesterol (-6.0%; P=0.012) and LDL/HDL ratio (-6.5%; P=0.041). The Reynolds risk assessment score for cardiovascular disease was decreased in the rose hip group compared with the control group (-17%; P=0.007). Body weight, diastolic blood pressure, glucose tolerance, and plasma levels of high-density lipoprotein (HDL) cholesterol, triglycerides, incretins and markers of inflammation did not differ between the two groups.

Conclusions: Daily consumption of 40 g of rose hip powder for 6 weeks can significantly reduce cardiovascular risk in obese people through lowering of systolic blood pressure and plasma cholesterol levels.

Citing Articles

Inhibitory Mechanism of Polyphenol Extracts from Multi-Frequency Power Ultrasound-Pretreated Rose Flower Against α-Glucosidase.

Zhang C, Feng M, Chitrakar B, Yang F, Wei B, Wang B Foods. 2024; 13(21).

PMID: 39517205 PMC: 11544979. DOI: 10.3390/foods13213421.

Effects of Daily Intake of Rosehip Extract on Low-Density Lipoprotein Cholesterol and Blood Glucose Levels: A Systematic Review.

Belkhelladi M Cureus. 2024; 15(12):e51225.

PMID: 38283449 PMC: 10821714. DOI: 10.7759/cureus.51225.

Protective effects of fruit extract of and quercetin on human umbilical vein endothelial cell injury induced by hydrogen peroxide.

Forouzanfar F, Tabatabaei Z, Emami S, Ayati Z, Tayarani-Najaran Z Food Sci Nutr. 2023; 11(12):7618-7625.

PMID: 38107098 PMC: 10724588. DOI: 10.1002/fsn3.3681.

The Possibility of Using Fruit-Bearing Plants of Temperate Climate in the Treatment and Prevention of Diabetes.

Lysiak G, Szot I Life (Basel). 2023; 13(9).

PMID: 37763199 PMC: 10532890. DOI: 10.3390/life13091795.

The effect of endurance exercise and rosehip extract supplementation on the expression of P53 and cytochrome C genes in male rat heart.

Abdollahi-Diba M, Bashiri J, Pourmanaf H, Fekri-Kourabbaslou V J Cardiovasc Thorac Res. 2023; 14(4):246-252.

PMID: 36699555 PMC: 9871160. DOI: 10.34172/jcvtr.2022.31599.

References

Willich S, Rossnagel K, Roll S, Wagner A, Mune O, Erlendson J . Rose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trial. Phytomedicine. 2009; 17(2):87-93. DOI: 10.1016/j.phymed.2009.09.003. View

Bukowska H, Jastrzebska M, Chelstowski K, Naruszewicz M . Decrease in fibrinogen and LDL-cholesterol levels upon supplementation of diet with Lactobacillus plantarum in subjects with moderately elevated cholesterol. Atherosclerosis. 1998; 137(2):437-8. DOI: 10.1016/s0021-9150(97)00283-9. View

Chrubasik C, Roufogalis B, Muller-Ladner U, Chrubasik S . A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res. 2008; 22(6):725-33. DOI: 10.1002/ptr.2400. View

DeFronzo R . Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia. 2010; 53(7):1270-87. PMC: 2877338. DOI: 10.1007/s00125-010-1684-1. View

Ridker P, Paynter N, Rifai N, Gaziano J, Cook N . C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation. 2008; 118(22):2243-51, 4p following 2251. PMC: 2752381. DOI: 10.1161/CIRCULATIONAHA.108.814251. View

Streppel M, Arends L, van t Veer P, Grobbee D, Geleijnse J . Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med. 2005; 165(2):150-6. DOI: 10.1001/archinte.165.2.150. View

Hunninghake D, Miller V, Larosa J, Kinosian B, Jacobson T, Brown V . Long-term treatment of hypercholesterolemia with dietary fiber. Am J Med. 1994; 97(6):504-8. DOI: 10.1016/0002-9343(94)90344-1. View

Cani P, Delzenne N . Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol. 2009; 9(6):737-43. DOI: 10.1016/j.coph.2009.06.016. View

Chrubasik J, Roufogalis B, Chrubasik S . Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. Phytother Res. 2007; 21(7):675-83. DOI: 10.1002/ptr.2142. View

10.

Ninomiya K, Matsuda H, Kubo M, Morikawa T, Nishida N, Yoshikawa M . Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside. Bioorg Med Chem Lett. 2007; 17(11):3059-64. DOI: 10.1016/j.bmcl.2007.03.051. View

11.

Ridker P, Buring J, Rifai N, Cook N . Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA. 2007; 297(6):611-9. DOI: 10.1001/jama.297.6.611. View

12.

Jenkins D, Kendall C, Faulkner D, Nguyen T, Kemp T, Marchie A . Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Am J Clin Nutr. 2006; 83(3):582-91. DOI: 10.1093/ajcn.83.3.582. View

13.

Jenkins D, Kendall C, Marchie A, Faulkner D, Wong J, de Souza R . Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. JAMA. 2003; 290(4):502-10. DOI: 10.1001/jama.290.4.502. View

14.

Winther K, Rein E, Kharazmi A . The anti-inflammatory properties of rose-hip. Inflammopharmacology. 2007; 7(1):63-8. DOI: 10.1007/s10787-999-0026-8. View

15.

Holme I . An analysis of randomized trials evaluating the effect of cholesterol reduction on total mortality and coronary heart disease incidence. Circulation. 1990; 82(6):1916-24. DOI: 10.1161/01.cir.82.6.1916. View

16.

Winther K, Apel K, Thamsborg G . A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005; 34(4):302-8. DOI: 10.1080/03009740510018624. View

17.

Jager A, Eldeen I, Van Staden J . COX-1 and -2 activity of rose hip. Phytother Res. 2007; 21(12):1251-2. DOI: 10.1002/ptr.2236. View

18.

Unger R, Clark G, Scherer P, Orci L . Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim Biophys Acta. 2009; 1801(3):209-14. DOI: 10.1016/j.bbalip.2009.10.006. View

19.

Andersson U, Henriksson E, Strom K, Alenfall J, Goransson O, Holm C . Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab. 2010; 300(1):E111-21. DOI: 10.1152/ajpendo.00268.2010. View

20.

Katan M, Grundy S, Jones P, Law M, Miettinen T, Paoletti R . Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc. 2003; 78(8):965-78. DOI: 10.4065/78.8.965. View