Atherogenic Dyslipidemia and Cardiovascular Risk in Children with Nonalcoholic Fatty Liver Disease

Overview

Journal Clin Lipidol

Date 2011 Dec 14

PMID 22162978

Citations 17

Authors

Naim Alkhouri

Christine Carter-Kent

Michael Elias

Ariel E Feldstein

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic fatty liver disease is now regarded as the most common form of chronic liver disease in adults and children. The close association between nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome has been extensively described. Moreover, a growing body of evidence suggest that NAFLD by itself confers a substantial cardiovascular risk independent of the other components of the metabolic syndrome. Given the significant potential for morbidity and mortality in these patients, and the large proportion of both pediatric and adult population affected, it is important that we clearly define the overall risk, identify early predictors for cardiovascular disease progression, and establish management strategies. In this article, we will focus on current data linking NAFLD and the severity of liver damage present in children with cardiovascular risk.

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References

Targher G . Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens. Diabet Med. 2007; 24(1):1-6. DOI: 10.1111/j.1464-5491.2007.02025.x. View

Browning J, Horton J . Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. 2004; 114(2):147-52. PMC: 449757. DOI: 10.1172/JCI22422. View

Yoneda M, Mawatari H, Fujita K, Iida H, Yonemitsu K, Kato S . High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH. J Gastroenterol. 2007; 42(7):573-82. DOI: 10.1007/s00535-007-2060-x. View

Weisberg S, McCann D, Desai M, Rosenbaum M, Leibel R, Ferrante Jr A . Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112(12):1796-808. PMC: 296995. DOI: 10.1172/JCI19246. View

Kantartzis K, Rittig K, Cegan A, Machann J, Schick F, Balletshofer B . Fatty liver is independently associated with alterations in circulating HDL2 and HDL3 subfractions. Diabetes Care. 2007; 31(2):366-8. DOI: 10.2337/dc07-1558. View

Sookoian S, Pirola C . Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review. J Hepatol. 2008; 49(4):600-7. DOI: 10.1016/j.jhep.2008.06.012. View

Wei C, Ford A, Hunt L, Crowne E, Shield J . Abnormal liver function in children with metabolic syndrome from a UK-based obesity clinic. Arch Dis Child. 2010; 96(11):1003-7. DOI: 10.1136/adc.2010.190975. View

Schwimmer J, Pardee P, Lavine J, Blumkin A, Cook S . Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation. 2008; 118(3):277-83. PMC: 2996820. DOI: 10.1161/CIRCULATIONAHA.107.739920. View

Kang H, Gutin B, Barbeau P, Litaker M, Allison J, Le N . Low-density lipoprotein particle size, central obesity, cardiovascular fitness, and insulin resistance syndrome markers in obese youths. Int J Obes Relat Metab Disord. 2002; 26(8):1030-5. DOI: 10.1038/sj.ijo.0802045. View

10.

Hotamisligil G . Inflammation and metabolic disorders. Nature. 2006; 444(7121):860-7. DOI: 10.1038/nature05485. View

11.

Gomez Rosso L, Benitez M, Cecilia Fornari M, Berardi V, Lynch S, Schreier L . Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome. Atherosclerosis. 2007; 199(2):415-23. DOI: 10.1016/j.atherosclerosis.2007.11.007. View

12.

Gibson P, Cuthbertson B, Croal B, Rae D, El-Shafei H, Gibson G . Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 2010; 105(2):186-91. DOI: 10.1016/j.amjcard.2009.09.007. View

13.

Walldius G, Jungner I . Apolipoprotein B and apolipoprotein A-I: risk indicators of coronary heart disease and targets for lipid-modifying therapy. J Intern Med. 2004; 255(2):188-205. DOI: 10.1046/j.1365-2796.2003.01276.x. View

14.

Cai D, Yuan M, Frantz D, Melendez P, Hansen L, Lee J . Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005; 11(2):183-90. PMC: 1440292. DOI: 10.1038/nm1166. View

15.

Tamhane U, Aneja S, Montgomery D, Rogers E, Eagle K, Gurm H . Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008; 102(6):653-7. DOI: 10.1016/j.amjcard.2008.05.006. View

16.

Lebensztejn D, Wojtkowska M, Skiba E, Werpachowska I, Tobolczyk J, Kaczmarski M . Serum concentration of adiponectin, leptin and resistin in obese children with non-alcoholic fatty liver disease. Adv Med Sci. 2009; 54(2):177-82. DOI: 10.2478/v10039-009-0047-y. View

17.

Fleischman A, Shoelson S, Bernier R, Goldfine A . Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care. 2007; 31(2):289-94. PMC: 3226794. DOI: 10.2337/dc07-1338. View

18.

Brunt E . Pathology of fatty liver disease. Mod Pathol. 2007; 20 Suppl 1:S40-8. DOI: 10.1038/modpathol.3800680. View

19.

Azab B, Zaher M, Weiserbs K, Torbey E, Lacossiere K, Gaddam S . Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol. 2010; 106(4):470-6. DOI: 10.1016/j.amjcard.2010.03.062. View

20.

Chan D, Li A, Chu W, Chan M, Wong E, Liu E . Hepatic steatosis in obese Chinese children. Int J Obes Relat Metab Disord. 2004; 28(10):1257-63. DOI: 10.1038/sj.ijo.0802734. View