Shining a Light on Intestinal Traffic

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2011 Dec 14

PMID 22162719

Citations 3

Authors

Carola T Murphy

Kenneth Nally

Fergus Shanahan

Silvia Melgar

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. Thus, leukocyte trafficking is a major target for IBD therapy. Past and emerging techniques to study leukocyte trafficking both in vitro and in vivo have expanded our knowledge of the leukocyte migration process and the role of inhibitors. Various strategies have been employed to target chemokine- and integrin-ligand interactions within the multistep adhesion cascade and the S1P/S1PR1 axis in leukocyte migration. Though there is an abundance of preclinical data demonstrating efficacy of leukocyte trafficking inhibitors, many have yet to be confirmed in clinical studies. Vigilance for toxicity and further research is required into this complex and emerging area of IBD therapy.

Citing Articles

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References

Daniel C, Sartory N, Zahn N, Schmidt R, Geisslinger G, Radeke H . FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. Mol Immunol. 2007; 44(13):3305-16. DOI: 10.1016/j.molimm.2007.02.026. View

Yacyshyn B, Chey W, Wedel M, Yu R, Paul D, Chuang E . A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease. Clin Gastroenterol Hepatol. 2007; 5(2):215-20. DOI: 10.1016/j.cgh.2006.11.001. View

Ammit A, Hastie A, Edsall L, Hoffman R, Amrani Y, Krymskaya V . Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J. 2001; 15(7):1212-4. DOI: 10.1096/fj.00-0742fje. View

Miller M, Wei S, Cahalan M, Parker I . Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A. 2003; 100(5):2604-9. PMC: 151387. DOI: 10.1073/pnas.2628040100. View

Rivera-Nieves J, Olson T, Bamias G, Bruce A, Solga M, Knight R . L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. J Immunol. 2005; 174(4):2343-52. DOI: 10.4049/jimmunol.174.4.2343. View

Bommakanti S, Patil A, Eshoa C, Chitambar C . Case reports: efalizumab-associated lymphoproliferative disease. J Drugs Dermatol. 2007; 6(6):646-8. View

Bonecchi R, Bianchi G, Bordignon P, DAmbrosio D, Lang R, Borsatti A . Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 1998; 187(1):129-34. PMC: 2199181. DOI: 10.1084/jem.187.1.129. View

Tedesco-Silva H, Mourad G, Kahan B, Boira J, Weimar W, Mulgaonkar S . FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. Transplantation. 2005; 79(11):1553-60. View

Sperandio M . Selectins and glycosyltransferases in leukocyte rolling in vivo. FEBS J. 2006; 273(19):4377-89. DOI: 10.1111/j.1742-4658.2006.05437.x. View

10.

Wermers J, McNamee E, Wurbel M, Jedlicka P, Rivera-Nieves J . The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice. Gastroenterology. 2011; 140(5):1526-35.e3. PMC: 3086928. DOI: 10.1053/j.gastro.2011.01.044. View

11.

Strober W, Fuss I, Mannon P . The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007; 117(3):514-21. PMC: 1804356. DOI: 10.1172/JCI30587. View

12.

Sadikot R, Blackwell T . Bioluminescence imaging. Proc Am Thorac Soc. 2005; 2(6):537-40, 511-2. PMC: 2713342. DOI: 10.1513/pats.200507-067DS. View

13.

Suarez Y, Wang C, Manes T, Pober J . Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation. J Immunol. 2009; 184(1):21-5. PMC: 2797568. DOI: 10.4049/jimmunol.0902369. View

14.

van Deventer S, Tami J, Wedel M . A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis. Gut. 2004; 53(11):1646-51. PMC: 1774281. DOI: 10.1136/gut.2003.036160. View

15.

Bolick D, Srinivasan S, Kim K, Hatley M, Clemens J, Whetzel A . Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler Thromb Vasc Biol. 2005; 25(5):976-81. DOI: 10.1161/01.ATV.0000162171.30089.f6. View

16.

Mizushima T, Ito T, Kishi D, Kai Y, Tamagawa H, Nezu R . Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflamm Bowel Dis. 2004; 10(3):182-92. DOI: 10.1097/00054725-200405000-00002. View

17.

Johansson-Lindbom B, Agace W . Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol Rev. 2007; 215:226-42. DOI: 10.1111/j.1600-065X.2006.00482.x. View

18.

Kawashima D, Oshitani N, Jinno Y, Watanabe K, Nakamura S, Higuchi K . Augmented expression of secondary lymphoid tissue chemokine and EBI1 ligand chemokine in Crohn's disease. J Clin Pathol. 2005; 58(10):1057-63. PMC: 1770738. DOI: 10.1136/jcp.2004.024828. View

19.

Ley K, Kansas G . Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol. 2004; 4(5):325-35. DOI: 10.1038/nri1351. View

20.

Sans M, Panes J, Ardite E, Elizalde J, Arce Y, Elena M . VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis. Gastroenterology. 1999; 116(4):874-83. DOI: 10.1016/s0016-5085(99)70070-3. View