The Insertion/deletion (I/D) Polymorphism in the Angiotensin-converting Enzyme Gene and Cancer Risk: a Meta-analysis

Overview

Journal BMC Med Genet

Publisher Biomed Central

Specialty Genetics

Date 2011 Dec 14

PMID 22151803

Citations 16

Authors

Yonggang Zhang

Jie He

Yao Deng

Jie Zhang

Xiaobo Li

Zhangpeng Xiang

Honglang Huang

Can Tian

Jin Huang

Hong Fan

Affiliations

Soon will be listed here.

Abstract

Background: The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I/D polymorphism in the ACE gene and cancer risk by meta-analysis.

Methods: A search was performed in Pubmed database, Embase database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI) database and Weipu database, covering all studies until August 31, 2010. Statistical analysis was performed by using Revman4.2 and STATA 10.0.

Results: A total of 25 case-control studies comprising 3914 cancer patients and 11391 controls were identified. No significant association was found between the I/D polymorphism and over all cancer risks (OR = 0.88, 95%CI = 0.73-1.06, P = 0.17 for DD+DI vs. II). In the subgroup analysis by ethnicity, no significant association was found among Asians and Europeans for the comparison of DD+DI vs. II. In the subgroup analysis by cancer types, no significant associations were found among lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated the lack of associations between this polymorphism and cancer risks.

Conclusions: This meta-analysis suggested that the ACE D/I polymorphism might not contribute to the risk of cancer.

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El Ezzi A, Clawson J, El-Saidi M, Zaidan W, Kovash A, Orellana J Prostate Cancer. 2020; 2020:5959134.

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