Cytogenetic Biomonitoring in Children Submitting to a Complete Set of Radiographs for Orthodontic Planning

Overview

Journal Angle Orthod

Specialty Dentistry

Date 2011 Dec 14

PMID 22149661

Citations 9

Authors

Diego Coelho Lorenzoni

Ana Carolina Cuzzuol Fracalossi

Viviane Carlin

Daniel Araki Ribeiro

Eduardo Franzotti Sant Anna

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from children undergoing orthodontic radiographs.

Materials And Methods: A total of 25 healthy children undergoing orthodontic therapy partook in a complete set of orthodontic radiographs (lateral cephalographic, posteroanterior cephalographic, panoramic, full periapical exam, and bitewing). The micronucleus test in the buccal exfoliated cells was applied. The paired-samples t-test and the Wilcoxon test were used to compare the frequencies of alterations before and after X-ray exposure.

Results: We found no statistically significant differences (P > .05) between micronucleated buccal mucosa cells before and after exposure to radiation. However, radiation did cause other nuclear alterations closely related to cytotoxicity (P = .007).

Conclusion: According to the micronucleus test, the complete set of radiographs requested in the orthodontic planning may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity.

Citing Articles

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Low-dose radiations derived from cone-beam CT induce transient DNA damage and persistent inflammatory reactions in stem cells from deciduous teeth.

Virag P, Hedesiu M, Soritau O, Perde-Schrepler M, Brie I, Pall E Dentomaxillofac Radiol. 2018; 48(1):20170462.

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