Diagnostic Performance of Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320 Row Detector Computed Tomography: Design and Implementation of the CORE320 Multicenter, Multinational Diagnostic Study

Overview

Journal J Cardiovasc Comput Tomogr

Publisher Elsevier

Specialties Cardiology & Vascular Diseases
Radiology

Date 2011 Dec 8

PMID 22146496

Citations 39

Authors

Andrea L Vavere

Gregory G Simon

Richard T George

Carlos E Rochitte

Andrew E Arai

Julie M Miller

Marcello Di Carli

Armin Arbab-Zadeh

Armin A Zadeh

Marc Dewey

Hiroyuki Niinuma

Roger Laham

Frank J Rybicki

Joanne D Schuijf

Narinder Paul

John Hoe

Sachio Kuribyashi

Hajime Sakuma

Cesar Nomura

Tan Swee Yaw

Klaus F Kofoed

Kunihiro Yoshioka

Melvin E Clouse

Jeffrey Brinker

Christopher Cox

Joao A C Lima

Affiliations

Soon will be listed here.

Abstract

Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography"). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.

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