Richard T George
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Explore the profile of Richard T George including associated specialties, affiliations and a list of published articles.
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Articles
85
Citations
1922
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0
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Recent Articles
1.
Papworth M, Kulkarni S, Antonsson M, Sermadiras I, Hovdal D, Connolly K, et al.
Cardiovasc Res
. 2025 Mar;
PMID: 40037346
Aim: Relaxin-2, a well-known human hormone primarily associated with pregnancy, has shown promising cardiovascular benefits in both preclinical models and clinical trials. However, its therapeutic potential has been limited due...
2.
Gaudet D, Greber-Platzer S, Reeskamp L, Iannuzzo G, Rosenson R, Saheb S, et al.
Eur Heart J
. 2024 Jun;
45(27):2422-2434.
PMID: 38856678
Background And Aims: Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder characterized by severely elevated LDL cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease. In the pivotal Phase 3 HoFH...
3.
Wiegman A, Greber-Platzer S, Ali S, Reijman M, Brinton E, Charng M, et al.
Circulation
. 2023 Oct;
149(5):343-353.
PMID: 37860863
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) levels due to profoundly defective LDL receptor (LDLR) function. Given that severely...
4.
Gannon M, Cerci R, Valdiviezo C, Ostovaneh M, Vavere A, de Vasconcellos H, et al.
Am J Cardiol
. 2023 Sep;
207:314-321.
PMID: 37774472
Our objective is to use computed tomography angiography (CTA) and computed tomography perfusion (CTP) to identify the ischemic significance of myocardial bridging (MB). We also seek to determine the long-term...
5.
Vavere A, Sinsakul M, Ongstad E, Yang Y, Varma V, Jones C, et al.
J Am Heart Assoc
. 2023 Jan;
12(3):e027540.
PMID: 36688371
Background Blockade of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a potentially attractive mechanism for lowering inflammatory and lipid risk in patients with atherosclerosis. This study aims to assess...
6.
Bonaca M, Morrow D, Bergmark B, Berg D, Lima J, Hoffmann U, et al.
Circulation
. 2022 Aug;
146(12):907-916.
PMID: 36039762
Background: High-density lipoprotein plays a key role in reverse cholesterol transport. In addition, high-density lipoprotein particles may be cardioprotective and reduce infarct size in the setting of myocardial injury. Lecithin-cholesterol...
7.
Defilippis E, Echols M, Adamson P, Batchelor W, Cooper L, Cooper L, et al.
JAMA Cardiol
. 2022 Mar;
7(5):540-548.
PMID: 35319725
Importance: Despite bearing a disproportionate burden of heart failure (HF), Black and Hispanic individuals have been poorly represented in HF clinical trials. Underrepresentation in clinical trials limits the generalizability of...
8.
Ruff C, Koren M, Grimsby J, Rosenbaum A, Tu X, Karathanasis S, et al.
Arterioscler Thromb Vasc Biol
. 2021 Oct;
41(12):3005-3014.
PMID: 34706556
Objective: Functional HDL (high-density lipoprotein) particles that facilitate cholesterol efflux may be cardioprotective. EL (endothelial lipase) hydrolyzes phospholipids promoting catabolism of HDL and subsequent renal excretion. MEDI5884 is a selective,...
9.
George R, Abuhatzira L, Stoughton S, Karathanasis S, She D, Jin C, et al.
J Am Heart Assoc
. 2021 Jun;
10(13):e014572.
PMID: 34121413
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate-limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and benefit...
10.
Dewey M, Rochitte C, Ostovaneh M, Chen M, George R, Niinuma H, et al.
J Cardiovasc Comput Tomogr
. 2021 May;
15(6):485-491.
PMID: 34024757
Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single...