Diseases in a Dish: Modeling Human Genetic Disorders Using Induced Pluripotent Cells

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2011 Dec 8

PMID 22146428

Citations 96

Authors

Gustavo Tiscornia

Erica Lorenzo Vivas

Juan Carlos Izpisua Belmonte

Affiliations

Soon will be listed here.

Abstract

The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.

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