HIV Target Cells in Schistosoma Haematobium-infected Female Genital Mucosa

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2011 Dec 7

PMID 22144444

Citations 38

Authors

Peter Mark Jourdan

Sigve Dhondup Holmen

Svein Gunnar Gundersen

Borghild Roald

Eyrun Floerecke Kjetland

Affiliations

Soon will be listed here.

Abstract

The parasite Schistosoma haematobium frequently causes genital lesions in women and could increase the risk of human immunodeficiency virus (HIV) transmission. This study quantifies the HIV target cells in schistosome-infected female genital mucosa. Cervicovaginal biopsies with and without schistosomiasis were immunostained for quantification of CD4(+) T lymphocytes (CD3, CD8), macrophages (CD68), and dendritic Langerhans cells (S100 protein). We found significantly higher densities of genital mucosal CD4(+) T lymphocytes and macrophages surrounding schistosome ova compared with cervicovaginal mucosa without ova (P = 0.034 and P = 0.018, respectively). We found no increased density of Langerhans cells (P = 0.25). This study indicates that S. haematobium may significantly increase the density of HIV target cells (CD4(+) T lymphocytes and macrophages) in the female genitals, creating a beneficial setting for HIV transmission. Further studies are needed to confirm these findings and to evaluate the effect of anti-schistosomal treatment on female genital schistosomiasis.

Citing Articles

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