The Role of [¹⁸F]fluorodeoxyglucose Positron Emission Tomography in Thymic Epithelial Tumors

Overview

Journal Cancer Imaging

Publisher Springer Nature

Specialties Oncology
Radiology

Date 2011 Dec 6

PMID 22138614

Citations 12

Authors

Kyoichi Kaira

Noriaki Sunaga

Tamotsu Ishizuka

Kimihiro Shimizu

Nobuyuki Yamamoto

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to systemically review the available literature regarding the diagnostic performance of positron emission tomography (PET) using 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) in patients with thymic epithelial tumors. We reviewed 13 studies that evaluated the diagnostic role of thymic epithelial tumors with [18F]FDG-PET. [18F]FDG-PET is a useful radiological modality for differentiating between thymomas and thymic carcinoma. However, [18F]FDG-PET may not be useful for differentiating low-risk thymoma and high-risk thymoma. One paper reported that [18F]FDG-PET has a predictive significance for treatment and prognosis in thymic epithelial tumors. Two papers reported that the degree of [18F]FDG uptake in thymic epithelial tumors is based on glucose metabolism. [18F]FDG-PET may have a further use for radiological differential diagnosis of thymomas and thymic carcinomas.

Citing Articles

Current Roles of PET/CT in Thymic Epithelial Tumours: Which Evidences and Which Prospects? A Pictorial Review.

Lococo F, Chiappetta M, Triumbari E, Evangelista J, Congedo M, Pizzuto D Cancers (Basel). 2021; 13(23).

PMID: 34885200 PMC: 8656753. DOI: 10.3390/cancers13236091.

Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors.

Yajima T, Mogi A, Yamaki E, Onozato R, Kosaka T, Shirabe K Mol Clin Oncol. 2020; 13(6):85.

PMID: 33163181 PMC: 7642802. DOI: 10.3892/mco.2020.2155.

Metabolic Characterization of Anterior Mediastinal Masses by F-FDG PET/CT.

Koc Z, Ozcan P, Ayan E, Bozdogan Arpaci R Mol Imaging Radionucl Ther. 2020; 29(3):105-111.

PMID: 33094573 PMC: 7583747. DOI: 10.4274/mirt.galenos.2020.05657.

Surgical management of thymic epithelial tumors.

Shintani Y, Funaki S, Ose N, Kanou T, Fukui E, Kimura K Surg Today. 2020; 51(3):331-339.

PMID: 32647929 DOI: 10.1007/s00595-020-02070-y.

Quantitative analysis of metabolic parameters at F-fluorodeoxyglucose positron emission tomography in predicting malignant potential of anterior mediastinal tumors.

Yajima T, Mogi A, Shimizu K, Kosaka T, Ohtaki Y, Obayashi K Oncol Lett. 2020; 19(3):1865-1871.

PMID: 32194681 PMC: 7038926. DOI: 10.3892/ol.2020.11276.

References

RYAN H, Poloni M, McNULTY W, Elson D, Gassmann M, Arbeit J . Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 2000; 60(15):4010-5. View

Ishiwata K, Enomoto K, Sasaki T, Elsinga P, Senda M, Okazumi S . A feasibility study on L-[1-carbon-11]tyrosine and L-[methyl-carbon-11]methionine to assess liver protein synthesis by PET. J Nucl Med. 1996; 37(2):279-85. View

Hoffman J, Waskin H, Schifter T, Hanson M, Gray L, Rosenfeld S . FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS. J Nucl Med. 1993; 34(4):567-75. View

Ho C, Yu S, Yeung D . 11C-acetate PET imaging in hepatocellular carcinoma and other liver masses. J Nucl Med. 2003; 44(2):213-21. View

Endo M, Nakagawa K, Ohde Y, Okumura T, Kondo H, Igawa S . Utility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumors. Lung Cancer. 2008; 61(3):350-5. DOI: 10.1016/j.lungcan.2008.01.003. View

Nakajo M, Kajiya Y, Tani A, Yoneda S, Shirahama H, Higashi M . ¹⁸FDG PET for grading malignancy in thymic epithelial tumors: significant differences in ¹⁸FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: preliminary study. Eur J Radiol. 2010; 81(1):146-51. DOI: 10.1016/j.ejrad.2010.08.010. View

Igai H, Matsuura N, Tarumi S, Chang S, Misaki N, Go T . Usefulness of [18F]fluoro-2-deoxy-D-glucose positron emission tomography for predicting the World Health Organization malignancy grade of thymic epithelial tumors. Eur J Cardiothorac Surg. 2010; 40(1):143-5. DOI: 10.1016/j.ejcts.2010.09.009. View

Sung Y, Lee K, Kim B, Choi J, Shim Y, Yi C . 18F-FDG PET/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroups. J Nucl Med. 2006; 47(10):1628-34. View

Brock C, Meikle S, Price P . Does fluorine-18 fluorodeoxyglucose metabolic imaging of tumours benefit oncology?. Eur J Nucl Med. 1997; 24(6):691-705. DOI: 10.1007/BF00841411. View

10.

Inoue A, Tomiyama N, Tatsumi M, Ikeda N, Okumura M, Shiono H . (18)F-FDG PET for the evaluation of thymic epithelial tumors: Correlation with the World Health Organization classification in addition to dual-time-point imaging. Eur J Nucl Med Mol Imaging. 2009; 36(8):1219-25. DOI: 10.1007/s00259-009-1082-4. View

11.

Ceresoli G, Chiti A, Zucali P, Rodari M, Lutman R, Salamina S . Early response evaluation in malignant pleural mesothelioma by positron emission tomography with [18F]fluorodeoxyglucose. J Clin Oncol. 2006; 24(28):4587-93. DOI: 10.1200/JCO.2006.06.8999. View

12.

Kumar A, Regmi S, Dutta R, Kumar R, Gupta S, Das P . Characterization of thymic masses using (18)F-FDG PET-CT. Ann Nucl Med. 2009; 23(6):569-77. DOI: 10.1007/s12149-009-0283-z. View

13.

Elson D, RYAN H, Snow J, Johnson R, Arbeit J . Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 2000; 60(21):6189-95. View

14.

Higashi K, Ueda Y, Sakurai A, Mingwang X, Xu L, Murakami M . Correlation of Glut-1 glucose transporter expression with [(18)F]FDG uptake in non-small cell lung cancer. Eur J Nucl Med. 2014; 27(12):1778-85. DOI: 10.1007/s002590000367. View

15.

Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T . Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors. J Clin Oncol. 2010; 28(23):3746-53. DOI: 10.1200/JCO.2009.27.4662. View

16.

Kaira K, Murakami H, Miura S, Kaira R, Akamatsu H, Kimura M . 18F-FDG uptake on PET helps predict outcome and response after treatment in unresectable thymic epithelial tumors. Ann Nucl Med. 2010; 25(4):247-53. DOI: 10.1007/s12149-010-0455-x. View

17.

Luzzi L, Campione A, Gorla A, Vassallo G, Bianchi A, Biggi A . Role of fluorine-flurodeoxyglucose positron emission tomography/computed tomography in preoperative assessment of anterior mediastinal masses. Eur J Cardiothorac Surg. 2009; 36(3):475-9. DOI: 10.1016/j.ejcts.2009.03.055. View

18.

Sasaki M, Kuwabara Y, Ichiya Y, Akashi Y, Yoshida T, Nakagawa M . Differential diagnosis of thymic tumors using a combination of 11C-methionine PET and FDG PET. J Nucl Med. 1999; 40(10):1595-601. View

19.

Kubota K, Yamada S, Kondo T, Yamada K, Fukuda H, Fujiwara T . PET imaging of primary mediastinal tumours. Br J Cancer. 1996; 73(7):882-6. PMC: 2074273. DOI: 10.1038/bjc.1996.157. View

20.

El-Bawab H, Al-Sugair A, Rafay M, Hajjar W, Mahdy M, Al-Kattan K . Role of flourine-18 fluorodeoxyglucose positron emission tomography in thymic pathology. Eur J Cardiothorac Surg. 2007; 31(4):731-6. DOI: 10.1016/j.ejcts.2007.01.024. View