Preventing Sexually Transmitted Infections: Back to Basics

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2011 Dec 3

PMID 22133882

Citations 6

Authors

Anne Rompalo

Affiliations

Soon will be listed here.

Abstract

Sexually transmitted infections (STIs) have plagued humans for millennia and can result in chronic disease, pregnancy complications, infertility, and even death. Recent technological advances have led to a better understanding of the causative agents for these infections as well as aspects of their pathogenesis that might represent novel therapeutic targets. The articles in this Review Series provide excellent updates on the recent advances in understanding of the pathogenesis of some very important and persistent STIs and discuss the importance of considering each pathogen in the broader context of the environment of the individual who it infects.

Citing Articles

Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response.

Holub M, Stranikova A, Chalupa P, Arientova S, Roubalova K, Beran O Can J Infect Dis Med Microbiol. 2020; 2020:5640960.

PMID: 32047574 PMC: 7003255. DOI: 10.1155/2020/5640960.

Investigation of human papillomavirus prevalence in married women and molecular characterization and phylogenetic analysis of the virus.

Yayla A, Goktug Kadioglu B, Aydin A, Aktas O Obstet Gynecol Sci. 2019; 62(4):264-272.

PMID: 31338344 PMC: 6629982. DOI: 10.5468/ogs.2019.62.4.264.

Benzathine penicillin G for the management of early syphilis among HIV co-infected persons: A systematic review.

Niragira O, Ha S, Pogany L, Singh A Can Commun Dis Rep. 2018; 42(2):30-36.

PMID: 29770001 PMC: 5864310. DOI: 10.14745/ccdr.v42i02a02.

The risk of human papillomavirus infection for male fertility abnormality: a meta-analysis.

Xiong Y, Chen Y, Cheng M, He W, Chen Q Asian J Androl. 2018; 20(5):493-497.

PMID: 29623908 PMC: 6116676. DOI: 10.4103/aja.aja_77_17.

Point of care diagnostics for sexually transmitted infections: perspectives and advances.

Gaydos C, Hardick J Expert Rev Anti Infect Ther. 2014; 12(6):657-72.

PMID: 24484215 PMC: 4065592. DOI: 10.1586/14787210.2014.880651.

References

Brotman R . Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest. 2011; 121(12):4610-7. PMC: 3225992. DOI: 10.1172/JCI57172. View

Ho E, Lukehart S . Syphilis: using modern approaches to understand an old disease. J Clin Invest. 2011; 121(12):4584-92. PMC: 3225993. DOI: 10.1172/JCI57173. View

Roest R, Carman W, Maertzdorf J, Scoular A, Harvey J, Kant M . Genotypic analysis of sequential genital herpes simplex virus type 1 (HSV-1) isolates of patients with recurrent HSV-1 associated genital herpes. J Med Virol. 2004; 73(4):601-4. DOI: 10.1002/jmv.20132. View

Johnston C, Koelle D, Wald A . HSV-2: in pursuit of a vaccine. J Clin Invest. 2011; 121(12):4600-9. PMC: 3223069. DOI: 10.1172/JCI57148. View

Posavad C, Remington M, Mueller D, Zhao L, Magaret A, Wald A . Detailed characterization of T cell responses to herpes simplex virus-2 in immune seronegative persons. J Immunol. 2010; 184(6):3250-9. PMC: 2877513. DOI: 10.4049/jimmunol.0900722. View

Riviere G, Wagoner M, Weisz K, Adams D, SIMONSON L, Lukehart S . Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis. N Engl J Med. 1991; 325(8):539-43. DOI: 10.1056/NEJM199108223250803. View

Nugent R, Krohn M, Hillier S . Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol. 1991; 29(2):297-301. PMC: 269757. DOI: 10.1128/jcm.29.2.297-301.1991. View

LaFond R, Molini B, Van Voorhis W, Lukehart S . Antigenic variation of TprK V regions abrogates specific antibody binding in syphilis. Infect Immun. 2006; 74(11):6244-51. PMC: 1695500. DOI: 10.1128/IAI.00827-06. View

Roest R, Maertzdorf J, Kant M, van der Meijden W, Osterhaus A, Verjans G . High incidence of genotypic variance between sequential herpes simplex virus type 2 isolates from HIV-1-seropositive patients with recurrent genital herpes. J Infect Dis. 2006; 194(8):1115-8. DOI: 10.1086/507683. View

10.

Workowski K, Berman S . Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010; 59(RR-12):1-110. View

11.

Zhou P, Li K, Lu H, Qian Y, Gu X, Gong W . Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai. Sex Transm Dis. 2010; 37(11):726-9. PMC: 3114640. DOI: 10.1097/OLQ.0b013e3181e2c753. View

12.

Gravitt P . The known unknowns of HPV natural history. J Clin Invest. 2011; 121(12):4593-9. PMC: 3225991. DOI: 10.1172/JCI57149. View

13.

Tapsall J . Neisseria gonorrhoeae and emerging resistance to extended spectrum cephalosporins. Curr Opin Infect Dis. 2009; 22(1):87-91. DOI: 10.1097/QCO.0b013e328320a836. View

14.

Stanberry L, Spruance S, Cunningham A, Bernstein D, Mindel A, Sacks S . Glycoprotein-D-adjuvant vaccine to prevent genital herpes. N Engl J Med. 2002; 347(21):1652-61. DOI: 10.1056/NEJMoa011915. View

15.

Crespi C, Cumberland W, Wald A, Corey L, Blower S . Longitudinal study of herpes simplex virus type 2 infection using viral dynamic modelling. Sex Transm Infect. 2007; 83(5):359-64. PMC: 2659025. DOI: 10.1136/sti.2006.022020. View

16.

Looker K, Garnett G, Schmid G . An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ. 2008; 86(10):805-12, A. PMC: 2649511. DOI: 10.2471/blt.07.046128. View

17.

Schiffer J, Abu-Raddad L, Mark K, Zhu J, Selke S, Magaret A . Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Sci Transl Med. 2010; 1(7):7ra16. PMC: 2818652. DOI: 10.1126/scitranslmed.3000193. View

18.

Lukehart S, Godornes C, Molini B, Sonnett P, Hopkins S, Mulcahy F . Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med. 2004; 351(2):154-8. DOI: 10.1056/NEJMoa040216. View

19.

Fraser C, Norris S, Weinstock G, White O, Sutton G, Dodson R . Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science. 1998; 281(5375):375-88. DOI: 10.1126/science.281.5375.375. View

20.

Cohen J . Immunology. Painful failure of promising genital herpes vaccine. Science. 2010; 330(6002):304. DOI: 10.1126/science.330.6002.304. View