Host-parasite Relationship in Cystic Echinococcosis: an Evolving Story

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2011 Nov 24

PMID 22110535

Citations 56

Authors

Alessandra Siracusano

Federica Delunardo

Antonella Teggi

Elena Ortona

Affiliations

Soon will be listed here.

Abstract

The larval stage of Echinococcus granulosus causes cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. Despite being under constant barrage by the immune system, E. granulosus modulates antiparasite immune responses and persists in the human hosts with detectable humoral and cellular responses against the parasite. In vitro and in vivo immunological approaches, together with molecular biology and immunoproteomic technologies, provided us exciting insights into the mechanisms involved in the initiation of E. granulosus infection and the consequent induction and regulation of the immune response. Although the last decade has clarified many aspects of host-parasite relationship in human cystic echinococcosis, establishing the full mechanisms that cause the disease requires more studies. Here, we review some of the recent developments and discuss new avenues in this evolving story of E. granulosus infection in man.

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