Ceftriaxone Associated Urolithiasis in a Child with Hypercalciuria

Overview

Journal Hippokratia

Specialty General Medicine

Date 2011 Nov 24

PMID 22110305

Citations 7

Authors

V J Lozanovski

Z Gucev

V J Avramoski

I Kirovski

P Makreski

V Tasic

Affiliations

Soon will be listed here.

Abstract

We present a 5-year-old boy with pneumonia who complained of right lumbar pain on the 7(th) day of treatment with Ceftriaxone. Ultrasound examination revealed mild to moderate right hydronephrosis. Under spasmoanalgetic therapy and hydration there was spontaneous passage of three small calculi. Infrared spectroscopy showed that the calculi were composed of calcium-ceftriaxonate. Full metabolic investigation was performed and moderate hypercalciuria was detected, suggesting the role of hypercalciuria in ceftriaxone-associated nephrolithiasis.

Citing Articles

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Drug-Induced Urolithiasis in Pediatric Patients.

Sighinolfi M, Eissa A, Bevilacqua L, Zoeir A, Ciarlariello S, Morini E Paediatr Drugs. 2019; 21(5):323-344.

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Evaluation of hypercalciuria in patients receiving intravenous Cefotaxime.

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Progressive Pseudolithiasis Associated with the Intravenous Administration of Ceftriaxone in Patients with Central Nervous System Infections.

Tsukagoshi S, Ishizawa K, Hirayanagi K, Nagamine S, Makioka K, Fujita Y Intern Med. 2017; 56(23):3189-3192.

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Characterizing ceftriaxone-induced urolithiasis and its associated acute kidney injury: an animal study and Chinese clinical systematic review.

Zhang Y, Ning B, Zhu H, Cong X, Zhou L, Wang Q Int Urol Nephrol. 2016; 48(7):1061-9.

PMID: 27126355 DOI: 10.1007/s11255-016-1273-4.

References

Tasic V, Sofijanova A, Avramoski V . Nephrolithiasis in a child with acute pyelonephritis. Ceftriaxone-induced nephrolithiasis and biliary pseudolithiasis. Pediatr Nephrol. 2005; 20(10):1510-1, 1512-3. DOI: 10.1007/s00467-005-1909-6. View

Avci Z, Koktener A, Uras N, Catal F, Karadag A, Tekin O . Nephrolithiasis associated with ceftriaxone therapy: a prospective study in 51 children. Arch Dis Child. 2004; 89(11):1069-72. PMC: 1719698. DOI: 10.1136/adc.2003.044156. View

Blais C, Duperval R . Biliary pseudolithiasis in a child associated with 2 days of ceftriaxone therapy. Pediatr Radiol. 1994; 24(3):218-9. DOI: 10.1007/BF02012198. View

Biner B, Oner N, Celtik C, Bostancioglu M, Tuncbilek N, Guzel A . Ceftriaxone-associated biliary pseudolithiasis in children. J Clin Ultrasound. 2006; 34(5):217-22. DOI: 10.1002/jcu.20228. View

Papadopoulou F, Efremidis S, Karyda S, Badouraki M, Karatza E, Panteliadis C . Incidence of ceftriaxone-associated gallbladder pseudolithiasis. Acta Paediatr. 2000; 88(12):1352-5. DOI: 10.1080/080352599750030077. View

De Moor R, Egberts A, Schroder C . Ceftriaxone-associated nephrolithiasis and biliary pseudolithiasis. Eur J Pediatr. 1999; 158(12):975-7. DOI: 10.1007/s004310051261. View

Schaad U, Tschaeppeler H . Reversible ceftriaxone-associated biliary pseudolithiasis in children. Lancet. 1988; 2(8625):1411-3. DOI: 10.1016/s0140-6736(88)90596-x. View

Acun C, Erdem L, Sogut A, Erdem C, Tomac N, Gundogdu S . Gallbladder and urinary tract precipitations associated with ceftriaxone therapy in children: a prospective study. Ann Trop Paediatr. 2004; 24(1):25-31. DOI: 10.1179/027249304225013349. View

Prince J, Senac Jr M . Ceftriaxone-associated nephrolithiasis and biliary pseudolithiasis in a child. Pediatr Radiol. 2003; 33(9):648-51. DOI: 10.1007/s00247-003-0963-0. View

10.

Stojanovic V, Djuric Vijatov G . Nephrolithiasis caused by ceftriaxone in a 3-year-old child with ureteropelvic junction obstruction. Case Rep Med. 2009; 2009:365962. PMC: 2729447. DOI: 10.1155/2009/365962. View

11.

Daudon M, Jungers P . Drug-induced renal calculi: epidemiology, prevention and management. Drugs. 2004; 64(3):245-75. DOI: 10.2165/00003495-200464030-00003. View

12.

Bor O, Dinleyici E, Kebapci M, Aydogdu S . Ceftriaxone-associated biliary sludge and pseudocholelithiasis during childhood: a prospective study. Pediatr Int. 2004; 46(3):322-4. DOI: 10.1111/j.1328-0867.2004.01884.x. View

13.

Bonnet J, Abid L, Dabhar A, Levy A, Soulier Y, Blangy S . Early biliary pseudolithiasis during ceftriaxone therapy for acute pyelonephritis in children: a prospective study in 34 children. Eur J Pediatr Surg. 2001; 10(6):368-71. DOI: 10.1055/s-2008-1072393. View

14.

Cochat P, Cochat N, Jouvenet M, Floret D, Wright C, Martin X . Ceftriaxone-associated nephrolithiasis. Nephrol Dial Transplant. 1990; 5(11):974-6. DOI: 10.1093/ndt/5.11.974. View

15.

Palanduz A, Yalcin I, Tonguc E, Guler N, Ones U, Salman N . Sonographic assessment of ceftriaxone-associated biliary pseudolithiasis in children. J Clin Ultrasound. 2001; 28(4):166-8. DOI: 10.1002/(sici)1097-0096(200005)28:4<166::aid-jcu2>3.0.co;2-g. View

16.

Mohkam M, Karimi A, Gharib A, Daneshmand H, Khatami A, Ghojevand N . Ceftriaxone associated nephrolithiasis: a prospective study in 284 children. Pediatr Nephrol. 2007; 22(5):690-4. DOI: 10.1007/s00467-006-0401-2. View