Bedrest and Sarcopenia

Overview

Journal Curr Opin Clin Nutr Metab Care

Specialty General Medicine

Date 2011 Nov 24

PMID 22108096

Citations 21

Authors

Robert H Coker

Robert R Wolfe

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The primary focus of this review is to characterize the physiological elements of sarcopenia. In addition, we will also describe the impact of bedrest on sarcopenia and how various countermeasures may be able to offset the deleterious clinical consequences of unanticipated bedrest or hospitalization. It is well known that the aging process presents many challenges to the maintenance of overall health. With the increasing rate of obesity and the potentially simultaneous development of sarcopenia, bedrest presents a difficult clinical challenge to the elderly individual.

Recent Findings: The etiology of accelerated sarcopenia has been described as a syndrome. The characteristics of this syndrome include combined alterations in neuromuscular control and muscle protein synthesis that increase the risk of morbidity and mortality in the elderly population. Moreover, the acute onset of bedrest-induced insulin resistance may further complicate the nutritionally derived maintenance of muscle mass and physical function.

Summary: Even though many questions remain unresolved concerning the optimal clinical management of elderly individuals who undergo unanticipated bedrest, the supplementation of essential amino acids has shown promise as a therapeutic strategy to minimize the detrimental influence of hospitalization in the elderly. In turn, this nutritional adjunctive therapy may reduce the length of stay and the likelihood of repeated hospitalization.

Citing Articles

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The Good, the Bad, and the Serum Creatinine: Exploring the Effect of Muscle Mass and Nutrition.

De Rosa S, Greco M, Rauseo M, Annetta M Blood Purif. 2023; 52(9-10):775-785.

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Cost-effectiveness analysis of sarcopenia management interventions in Iran.

Darvishi A, Shafiee G, Zargar Balajam N, Hemami M, Ostovar N, Heshmat R BMC Public Health. 2023; 23(1):819.

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Physical Fitness Differences, Amenable to Hypoxia-Driven and Sarcopenia Pathophysiology, between Sleep Apnea and COVID-19.

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Li H, Xiao W, He Y, Wen Z, Cheng S, Zhang Y Front Cell Dev Biol. 2022; 9:766020.

PMID: 35024366 PMC: 8743268. DOI: 10.3389/fcell.2021.766020.

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