Functional Network Organization of the Human Brain

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2011 Nov 22

PMID 22099467

Citations 2017

Authors

Jonathan D Power

Alexander L Cohen

Steven M Nelson

Gagan S Wig

Kelly Anne Barnes

Jessica A Church

Alecia C Vogel

Timothy O Laumann

Fran M Miezin

Bradley L Schlaggar

Steven E Petersen

Affiliations

Soon will be listed here.

Abstract

Real-world complex systems may be mathematically modeled as graphs, revealing properties of the system. Here we study graphs of functional brain organization in healthy adults using resting state functional connectivity MRI. We propose two novel brain-wide graphs, one of 264 putative functional areas, the other a modification of voxelwise networks that eliminates potentially artificial short-distance relationships. These graphs contain many subgraphs in good agreement with known functional brain systems. Other subgraphs lack established functional identities; we suggest possible functional characteristics for these subgraphs. Further, graph measures of the areal network indicate that the default mode subgraph shares network properties with sensory and motor subgraphs: it is internally integrated but isolated from other subgraphs, much like a "processing" system. The modified voxelwise graph also reveals spatial motifs in the patterning of systems across the cortex.

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