Silanol As a Removable Directing Group for the Pd(II)-catalyzed Direct Olefination of Arenes

Overview

Journal Chemistry

Specialty Chemistry

Date 2011 Nov 19

PMID 22095863

Citations 7

Authors

Cong Wang

Haibo Ge

Affiliations

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Abstract

Need some direction? Silanol was developed as a directing group for the Pd(II)-catalyzed oxidative Heck-type reaction of arenes. A one-pot C-H activation/desilylation process of benzyldiisopropylsilanol was also demonstrated, providing a powerful approach for the synthesis of ortho-alkenyl-substituted alkylarenes. Considering the easily attachable and readily removable properties of the silanol group, this reaction will find broad synthetic applications.

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