High Glucose Promotes Pancreatic Cancer Cell Proliferation Via the Induction of EGF Expression and Transactivation of EGFR

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2011 Nov 17

PMID 22087246

Citations 74

Authors

Liang Han

Qingyong Ma

Junhui Li

Han Liu

Wei Li

Guodong Ma

QinHong Xu

Shuang Zhou

Erxi Wu

Affiliations

Soon will be listed here.

Abstract

Multiple lines of evidence suggest that a large portion of pancreatic cancer patients suffer from either hyperglycemia or diabetes, both of which are characterized by high blood glucose level. However, the underlying biological mechanism of this phenomenon is largely unknown. In the present study, we demonstrated that the proliferative ability of two human pancreatic cancer cell lines, BxPC-3 and Panc-1, was upregulated by high glucose in a concentration-dependent manner. Furthermore, the promoting effect of high glucose levels on EGF transcription and secretion but not its receptors in these PC cell lines was detected by using an EGF-neutralizing antibody and RT-PCR. In addition, the EGFR transactivation is induced by high glucose levels in concentration- and time-dependent manners in PC cells in the presence of the EGF-neutralizing antibody. These results suggest that high glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR. Our findings may provide new insight on the links between high glucose level and PC in terms of the molecular mechanism and reveal a novel therapeutic strategy for PC patients who simultaneously suffer from either diabetes or hyperglycemia.

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