Is a Daily Supplementation with 40 Microgram Vitamin D3 Sufficient? A Randomised Controlled Trial

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2011 Nov 17

PMID 22086300

Citations 8

Authors

Goran Toss

Per Magnusson

Affiliations

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Abstract

Purpose: The effect of 40 μg (1,600 IU) per day of vitamin D(3) on serum 25-hydroxyvitamin D (25(OH)D) and markers of bone and mineral metabolism was evaluated.

Methods: This intervention study was designed as a double-blind randomised controlled trial. Forty-five community-dwelling subjects (32 females), age 55-84 years, at 58° North latitude were supplemented for 1 year with 40 μg vitamin D(3) plus 1,000 mg calcium per day, or with 1,000 mg calcium per day for controls. Safety parameters and 25(OH)D, intact parathyroid hormone (PTH), ionized calcium, bone-specific alkaline phosphatase (BALP), and tartrate-resistant acid phosphatase isoform 5b (TRACP5b) were measured over the study period.

Results: All subjects supplemented with vitamin D(3) reached a 25(OH)D level above 50 nmol/L. Mean (SD) serum 25(OH)D increased from 50.4 (13.5) nmol/L to 84.2 (17.5) nmol/L, range 55.0-125.0 nmol/L in the vitamin D(3) supplemented group and the corresponding levels for the control group were 47.3 (14.1) nmol/L and 45.7 (13.4) nmol/L, range 26.0-73.0 nmol/L. No serious adverse event was recorded and the highest 25(OH)D level reached, 125.0 nmol/L, is well below toxic levels. BALP and TRACP5b did not change significantly over the study period.

Conclusions: This trial suggests that a daily supplementation with 40 μg vitamin D(3) is sufficient to secure a 25(OH)D level of 50 nmol/L. No side effects were observed in the study group.

Citing Articles

Vitamin D Supplementation and Its Impact on Mortality and Cardiovascular Outcomes: Systematic Review and Meta-Analysis of 80 Randomized Clinical Trials.

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PMID: 37111028 PMC: 10146299. DOI: 10.3390/nu15081810.

A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe.

Mo M, Wang S, Chen Z, Muyiduli X, Wang S, Shen Y Eur J Clin Nutr. 2019; 73(6):816-834.

PMID: 30872787 DOI: 10.1038/s41430-019-0417-x.

Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.

Mirhosseini N, Rainsbury J, Kimball S Front Cardiovasc Med. 2018; 5:87.

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Vitamin D₃ and 25-Hydroxyvitamin D₃ Content of Retail White Fish and Eggs in Australia.

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Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation.

Weaver C, Alexander D, Boushey C, Dawson-Hughes B, Lappe J, LeBoff M Osteoporos Int. 2015; 27(1):367-76.

PMID: 26510847 PMC: 4715837. DOI: 10.1007/s00198-015-3386-5.

References

Steingrimsdottir L, Gunnarsson O, Indridason O, Franzson L, Sigurdsson G . Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA. 2005; 294(18):2336-41. DOI: 10.1001/jama.294.18.2336. View

CHAPUY M, Pamphile R, Paris E, Kempf C, Schlichting M, Arnaud S . Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int. 2002; 13(3):257-64. DOI: 10.1007/s001980200023. View

Zittermann A, Scheld K, Stehle P . Seasonal variations in vitamin D status and calcium absorption do not influence bone turnover in young women. Eur J Clin Nutr. 1998; 52(7):501-6. DOI: 10.1038/sj.ejcn.1600591. View

Halleen J, Alatalo S, Suominen H, Cheng S, Janckila A, Vaananen H . Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption. J Bone Miner Res. 2000; 15(7):1337-45. DOI: 10.1359/jbmr.2000.15.7.1337. View

Vieth R, Chan P, MacFarlane G . Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001; 73(2):288-94. DOI: 10.1093/ajcn/73.2.288. View

Wortsman J, Matsuoka L, Chen T, Lu Z, Holick M . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72(3):690-3. DOI: 10.1093/ajcn/72.3.690. View

Dukas L, Staehelin H, Schacht E, Bischoff H . Better functional mobility in community-dwelling elderly is related to D-hormone serum levels and to daily calcium intake. J Nutr Health Aging. 2005; 9(5):347-51. View

Dawson-Hughes B, Heaney R, Holick M, Lips P, Meunier P, Vieth R . Estimates of optimal vitamin D status. Osteoporos Int. 2005; 16(7):713-6. DOI: 10.1007/s00198-005-1867-7. View

Viljakainen H, Palssa A, Karkkainen M, Jakobsen J, Lamberg-Allardt C . How much vitamin D3 do the elderly need?. J Am Coll Nutr. 2006; 25(5):429-35. DOI: 10.1080/07315724.2006.10719556. View

10.

Gomez Jr B, Ardakani S, Ju J, Jenkins D, Cerelli M, Daniloff G . Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum. Clin Chem. 1995; 41(11):1560-6. View

11.

Schleithoff S, Zittermann A, Tenderich G, Berthold H, Stehle P, Koerfer R . Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006; 83(4):754-9. DOI: 10.1093/ajcn/83.4.754. View

12.

Bischoff-Ferrari H, Orav E, Dawson-Hughes B . Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med. 2006; 166(4):424-30. DOI: 10.1001/archinte.166.4.424. View

13.

Sanders K, Stuart A, Williamson E, Simpson J, Kotowicz M, Young D . Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010; 303(18):1815-22. DOI: 10.1001/jama.2010.594. View

14.

Ross A, Manson J, Abrams S, Aloia J, Brannon P, Clinton S . The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2010; 96(1):53-8. PMC: 3046611. DOI: 10.1210/jc.2010-2704. View

15.

Savoca R, Bock A, Kraenzlin M, Schmid H, Huber A . An automated 'bio-intact' PTH assay: a step towards standardisation and improved correlation with parathyroid function in renal disease. Clin Chim Acta. 2004; 343(1-2):167-71. DOI: 10.1016/j.cccn.2004.01.024. View

16.

Heaney R, Armas L, Shary J, Bell N, Binkley N, Hollis B . 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr. 2008; 87(6):1738-42. DOI: 10.1093/ajcn/87.6.1738. View

17.

Cashman K, Hill T, Lucey A, Taylor N, Seamans K, Muldowney S . Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr. 2008; 88(6):1535-42. DOI: 10.3945/ajcn.2008.26594. View

18.

Sharma O . Hypercalcemia in granulomatous disorders: a clinical review. Curr Opin Pulm Med. 2000; 6(5):442-7. DOI: 10.1097/00063198-200009000-00010. View

19.

Hathcock J, Shao A, Vieth R, Heaney R . Risk assessment for vitamin D. Am J Clin Nutr. 2007; 85(1):6-18. DOI: 10.1093/ajcn/85.1.6. View

20.

Podsiadlo D, Richardson S . The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991; 39(2):142-8. DOI: 10.1111/j.1532-5415.1991.tb01616.x. View