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Plasma Epstein-Barr Virus DNA Concentration and Clearance Rate As Novel Prognostic Factors for Metastatic Nasopharyngeal Carcinoma

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Journal Head Neck
Date 2011 Nov 16
PMID 22083949
Citations 32
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Abstract

Background: To investigate the pretreatment copy number and the clearance rate of plasma Epstein-Barr virus (EBV) DNA as novel prognostic outcome markers for metastatic nasopharyngeal carcinoma (NPC).

Methods: Seventy-three patients with metastatic NPC were treated at outpatient department. Plasma EBV DNA concentrations and half-life values of plasma viral clearance rates, were determined by real-time quantitative polymerase chain reaction.

Results: Treatment response evaluated after 3 to 6 months of treatment showed that the overall response rate was 53.5%. The pretreatment plasma EBV DNA concentrations and the half-life of plasma EBV DNA clearance rates had significant effects on treatment response and overall survival prediction. In the chemotherapy regimen, gemcitabine plus cisplatin had a better treatment outcome than the cisplatin plus oral UFT and calcium folinate-based regimens.

Conclusions: The pretreatment plasma EBV DNA copy number and their clearance rates are significant predictors for NPC treatment outcome.

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