Rod and Cone Visual Pigments and Phototransduction Through Pharmacological, Genetic, and Physiological Approaches

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2011 Nov 15

PMID 22074928

Citations 47

Authors

Vladimir J Kefalov

Affiliations

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Abstract

Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-cis-retinal, play a key role in shaping the light responses of photoreceptors. The combination of pharmacological, physiological, and genetic tools has been a powerful approach advancing our understanding of the interactions between opsin and chromophore and how they affect the function of visual pigments. The signaling properties of the visual pigments modulate many aspects of the function of rods and cones, producing their unique physiological properties.

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