Compatibility of Different Polymers for Cord Blood-derived Hematopoietic Progenitor Cells

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2011 Nov 11

PMID 22071984

Citations 3

Authors

Monica Ventura Ferreira

Norina Labude

Daniela Piroth

Willi Jahnen-Dechent

Ruth Knuchel

Thomas Hieronymus

Martin Zenke

Sabine Neuss

Affiliations

Soon will be listed here.

Abstract

The low yield of hematopoietic progenitor cells (HPC) present in cord blood grafts limits their application in clinics. A reliable strategy for ex vivo expansion of functional HPC is a present goal in regenerative medicine. Here we evaluate the capacity of several two-dimensional polymers to support HPC proliferation. Basic compatibility was tested by measuring cell viability, cytotoxicity and apoptosis of CD34(+) progenitors that were short and long-term exposed to sixteen bio and synthetic polymers. Resomer(®) RG503, PCL and Fibrin might be good alternatives to tissue culture plastic for culture of CB-derived CD34(+) progenitors. Further, these polymers will be produced in three-dimensional structures and tested for their cytocompatibility.

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