A Longitudinal Study of the Cognitive Function of Children with Renal Failure

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 1990 Jan 1

PMID 2206873

Citations 18

Authors

R S Fennell

E B Fennell

R L Carter

E L Mings

A B Klausner

J R Hurst

Affiliations

Soon will be listed here.

Abstract

Fifty-six children with chronic renal failure who either received a kidney transplant, were hemodialyzed or peritoneally dialyzed, or who were being medically managed were given a series of neuropsychological tests every 6 months for a total of four testing sessions. Each child was matched by age, sex, and race to healthy children who received the same sequence of tests. The performance of each treatment group was compared with their controls longitudinally, using a repeated measure analysis of variance. In general, renal subjects performed at lower levels than their controls on tasks of verbal ability, visual perception, memory and visual motor skills. Visual motor performance was the most clinically affected. When compared with controls, the renal subjects did not improve as much or actually deteriorated on some measures of memory and learning skills.

Citing Articles

Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature.

Lullmann O, van der Plas E, Harshman L Pediatr Transplant. 2023; 27(8):e14597.

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Neurocognitive deficits may not resolve following pediatric kidney transplantation.

Lullmann O, Conrad A, Steinbach E, Wilgenbusch T, Harshman L, van der Plas E Pediatr Transplant. 2023; 27(4):e14505.

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Executive Functioning in Pediatric Solid Organ Transplant Recipients: A Meta-analytic Review.

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Psychosocial considerations and recommendations for care of pediatric patients on dialysis.

Clementi M, Zimmerman C Pediatr Nephrol. 2019; 35(5):767-775.

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Neurocognitive and functional outcomes at 5 years of age after renal transplant in early childhood.

Popel J, Joffe R, Acton B, Bond G, Joffe A, Midgley J Pediatr Nephrol. 2018; 34(5):889-895.

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References

Buschke H, Fuld P . Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology. 1974; 24(11):1019-25. DOI: 10.1212/wnl.24.11.1019. View

Rasbury W, Fennell 3rd R, Fennell E, Morris M . Cognitive functioning in children with end stage renal disease pre- and post-dialysis session. Int J Pediatr Nephrol. 1986; 7(1):45-50. View

Peterson L, Peterson M . Short-term retention of individual verbal items. J Exp Psychol. 1959; 58:193-8. DOI: 10.1037/h0049234. View

OSBERG J, Meares G, MCKEE D, Burnett G . Intellectual functioning in renal failure and chronic dialysis. J Chronic Dis. 1982; 35(6):445-57. DOI: 10.1016/0021-9681(82)90059-5. View

MORGAN S . Measuring long-term memory storage and retrieval in children. J Clin Neuropsychol. 1982; 4(1):77-85. DOI: 10.1080/01688638208401118. View

Fennell R, Fennell E, Carter R, Mings E, Klausner A, Hurst J . Association between renal function and cognition in childhood chronic renal failure. Pediatr Nephrol. 1990; 4(1):16-20. DOI: 10.1007/BF00858430. View

Rasbury W, Fennell 3rd R, Eastman B, Garin E, Richards G . Cognitive performance of children with renal disease. Psychol Rep. 1979; 45(1):231-9. DOI: 10.2466/pr0.1979.45.1.231. View

Ryan J, Souheaver G, DEWOLFE A . Intellectual deficit in chronic renal failure. A comparison with neurological and medical-psychiatric patients. J Nerv Ment Dis. 1980; 168(12):763-7. DOI: 10.1097/00005053-198012000-00010. View

Gilli P, De Bastiani P . Cognitive function and regular dialysis treatment. Clin Nephrol. 1983; 19(4):188-92. View

10.

GINN H, TESCHAN P, Walker P, Bourne J, Fristoe M, Ward J . Neurotoxicity in uremia. Kidney Int Suppl. 1975; (3):357-60. View

11.

Ratner D, Adams K, Levin N, Rourke B . Effects of hemodialysis on the cognitive and sensory-motor functioning of the adult chronic hemodialysis patient. J Behav Med. 1983; 6(3):291-311. DOI: 10.1007/BF01315115. View

12.

Crittenden M, HOLLIDAY M, Piel C, Potter D . Intellectual development of children with renal insufficiency and end stage disease. Int J Pediatr Nephrol. 1985; 6(4):275-80. View

13.

Fennell 3rd R, Rasbury W, Fennell E, Morris M . Effects of kidney transplantation on cognitive performance in a pediatric population. Pediatrics. 1984; 74(2):273-8. View

14.

English A, Savage R, Britton P, Ward M, Kerr D . Intellectual impairment in chronic renal failure. Br Med J. 1978; 1(6117):888-90. PMC: 1603764. DOI: 10.1136/bmj.1.6117.888. View

15.

Heilman K, Moyer R, Melendex F, Schwartz H, Miller B . A memory defect in uremic encephalopathy. J Neurol Sci. 1975; 26(2):245-9. DOI: 10.1016/0022-510x(75)90036-2. View

16.

Trieschmann R, Sand R . WAIS and MMPI correlates of increasing renal failure in adult medical patients. Psychol Rep. 1971; 29(3):1251-62. View

17.

Fennell E, Fennell R, Mings E, Morris M . The effects of various modes of therapy for end stage renal disease on cognitive performance in a pediatric population--a preliminary report. Int J Pediatr Nephrol. 1986; 7(2):107-12. View

18.

Ziesat Jr H, Logue P, McCarty S . Psychological measurement of memory deficits in dialysis patients. Percept Mot Skills. 1980; 50(1):311-8. DOI: 10.2466/pms.1980.50.1.311. View

19.

Rasbury W, Fennell 3rd R, Morris M . Cognitive functioning of children with end-stage renal disease before and after successful transplantation. J Pediatr. 1983; 102(4):589-92. DOI: 10.1016/s0022-3476(83)80194-2. View

20.

TESCHAN P, GINN H, Bourne J, Ward J . Neurobehavioral responses to "middle molecule" dialysis and transplantation. Trans Am Soc Artif Intern Organs. 1976; 22:190-4. View