Neuropsychological Functioning in End-stage Renal Disease

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 2004 Jun 24

PMID 15210497

Citations 10

Authors

H N Bawden

P Acott

J Carter

D Lirenman

G W Macdonald

M McAllister

M C McDonnell

S Shea

J Crocker

Affiliations

Soon will be listed here.

Abstract

Aims: To compare the neuropsychological functioning and behaviour of children with non-syndromic end-stage renal disease (ESRD) and sibling controls.

Methods: The study was carried out at two tertiary care paediatric teaching hospitals, in Halifax and Vancouver, Canada. Children with ESRD were on a renal transplant waiting list and either pending dialysis or on dialysis therapy. Twenty two patient-sibling pairs were evaluated. Neuropsychological assessments consisting of measures of intelligence, academic achievement, memory, and motor abilities were carried out. Maternal ratings of behaviour and self-report rating of self-esteem were collected.

Results: The Verbal, Performance, and Full Scale IQs of patients with ESRD were significantly lower than the IQs of the sibling controls. The mean differences were 8.6, 11.7, and 10.9 points, respectively. ESRD patients also had significantly more difficulty on measures of fine motor coordination and ability to copy geometric designs than sibling controls. There were no differences between groups on measures of academic achievement, memory, behaviour, or self-esteem.

Conclusions: Although children with ESRD exhibited mild deficits on measures of intelligence and some measures of motor abilities, their neuropsychological outcome was more favourable than earlier reports indicated.

Citing Articles

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Neuropsychological and neuroanatomical phenotype in 17 patients with cystinosis.

Curie A, Touil N, Gaillard S, Galanaud D, Leboucq N, Deschenes G Orphanet J Rare Dis. 2020; 15(1):59.

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Psychosocial considerations and recommendations for care of pediatric patients on dialysis.

Clementi M, Zimmerman C Pediatr Nephrol. 2019; 35(5):767-775.

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Neurocognitive and functional outcomes at 5 years of age after renal transplant in early childhood.

Popel J, Joffe R, Acton B, Bond G, Joffe A, Midgley J Pediatr Nephrol. 2018; 34(5):889-895.

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Moving on: transitioning young people with chronic kidney disease to adult care.

Francis A, Johnson D, Craig J, Wong G Pediatr Nephrol. 2017; 33(6):973-983.

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