Molecular Epidemiology and Characterisation of MRSA Isolates from Trinidad and Tobago

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 2011 Nov 10

PMID 22068275

Citations 8

Authors

S Monecke

H Nitschke

P Slickers

R Ehricht

W Swanston

M Manjunath

R Roberts

P E Akpaka

Affiliations

Soon will be listed here.

Abstract

Eighty methicillin-resistant Staphylococcus aureus (MRSA) isolates from three hospitals in Trinidad and Tobago were collected and genotyped using microarray hybridisation. They were found to belong to three distinct MRSA strains. Of the 80 isolates, 76 were assigned to ST239-MRSA-III. They were largely homogeneous, although some variations affected the presence of the enterotoxin A gene, as well as of resistance markers (mercury resistance operon, aadD, tet(K), qacA). The mupA gene conferring mupirocin resistance was found in 7.3% of isolates. One isolate was identified as CC5-MRSA-II and three isolates belonged to the Panton-Valentine leukocidin (PVL)-positive ST8-MRSA-IV strain USA300. While community-acquired MRSA strains are rare in Trinidad and Tobago, the vast majority of MRSA cases can be attributed to healthcare-associated strains. Thus, infection control procedures within medical facilities need to be revised and enforced. This could substantially reduce the burden of MRSA to healthcare in Trinidad and Tobago.

Citing Articles

Clonal Complexes Distribution of Isolates from Clinical Samples from the Caribbean Islands.

Monecke S, Akpaka P, Smith M, Unakal C, Thoms Rodriguez C, Ashraph K Antibiotics (Basel). 2023; 12(6).

PMID: 37370368 PMC: 10295549. DOI: 10.3390/antibiotics12061050.

Lateral Flow Immunoassay for the Detection of Panton-Valentine Leukocidin in From Skin and Soft Tissue Infections in the United Arab Emirates.

Senok A, Monecke S, Nassar R, Celiloglu H, Thyagarajan S, Muller E Front Cell Infect Microbiol. 2021; 11:754523.

PMID: 34733796 PMC: 8558463. DOI: 10.3389/fcimb.2021.754523.

Characterisation of a novel SCCmec VI element harbouring fusC in an emerging Staphylococcus aureus strain from the Arabian Gulf region.

Senok A, Slickers P, Hotzel H, Boswihi S, Braun S, Gawlik D PLoS One. 2019; 14(11):e0223985.

PMID: 31689288 PMC: 6830749. DOI: 10.1371/journal.pone.0223985.

Molecular Typing of ST239-MRSA-III From Diverse Geographic Locations and the Evolution of the SCC III Element During Its Intercontinental Spread.

Monecke S, Slickers P, Gawlik D, Muller E, Reissig A, Ruppelt-Lorz A Front Microbiol. 2018; 9:1436.

PMID: 30087657 PMC: 6066798. DOI: 10.3389/fmicb.2018.01436.

Dissemination of high-level mupirocin-resistant CC22-MRSA-IV in Saxony.

Monecke S, Ruppelt-Lorz A, Muller E, Reissig A, Thurmer A, Shore A GMS Hyg Infect Control. 2017; 12:Doc19.

PMID: 29184755 PMC: 5696886. DOI: 10.3205/dgkh000304.

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