Fitness Cost of Staphylococcal Cassette Chromosome Mec in Methicillin-resistant Staphylococcus Aureus by Way of Continuous Culture

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2007 Feb 7

PMID 17283194

Citations 45

Authors

Sui Mae Lee

Miriam Ender

Rajan Adhikari

John M B Smith

Brigitte Berger-Bachi

Gregory M Cook

Affiliations

Soon will be listed here.

Abstract

We examined the effect of introducing type I or IV staphylococcal cassette chromosome mec (SCCmec) elements on the growth yield of Staphylococcus aureus in glucose-limited continuous culture. Type I showed increased glucose consumption and ATP demand per gram of cells synthesized and decreased cell yield compared to those of the parent strain. In contrast, type IV SCCmec elements had no adverse energetic effect.

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