Activin A Stimulates Mouse APCs to Express BAFF Via ALK4-Smad3 Pathway

Overview

Journal Immune Netw

Specialty Allergy & Immunology

Date 2011 Nov 1

PMID 22039367

Citations 3

Authors

Jae-Hee Kim

Goo-Young Seo

Pyeung-Hyeun Kim

Affiliations

Soon will be listed here.

Abstract

Background: B cell-activating factor belonging to the TNF family (BAFF) is primarily expressed by macrophages and dendritic cells, and stimulates B cell proliferation, differentiation, survival, and Ig production. In the present study, we explored the effect of activin A on BAFF expression by APCs.

Methods: To investigate the effect of activin A on BAFF expression by mouse APCs, we measured the level of BAFF expression at the transcriptional and protein levels using RT-PCR and ELISA.

Results: Activin A markedly enhanced BAFF expression in mouse macrophages and dendritic cells at both the transcriptional and protein levels. SB431542, an activin receptor-like kinase 4 (ALK4) inhibitor, completely abrogated activin A-induced BAFF transcription. Furthermore, overexpression of DN-Smad3 abolished activin-induced BAFF expression at the transcriptional and protein levels.

Conclusion: These results demonstrate that activin A can enhance BAFF expression through ALK4-Smad3 pathway.

Citing Articles

Different Immunoregulation Roles of Activin A Compared With TGF-β.

Li F, Long Y, Yu X, Tong Y, Gong L Front Immunol. 2022; 13:921366.

PMID: 35774793 PMC: 9237220. DOI: 10.3389/fimmu.2022.921366.

In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.

Lin Y, Tsai N, Hsieh C, Ho S, Chang J, Wu H Proc Natl Acad Sci U S A. 2016; 113(48):E7798-E7807.

PMID: 27856749 PMC: 5137775. DOI: 10.1073/pnas.1604752113.

BAFF and APRIL from Activin A-Treated Dendritic Cells Upregulate the Antitumor Efficacy of Dendritic Cells In Vivo.

Shurin M, Ma Y, Keskinov A, Zhao R, Lokshin A, Agassandian M Cancer Res. 2016; 76(17):4959-69.

PMID: 27364554 PMC: 5010463. DOI: 10.1158/0008-5472.CAN-15-2668.

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