Detecting High-grade Squamous Intraepithelial Lesions in the Cervix with Quantitative Spectroscopy and Per-patient Normalization

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2011 Oct 26

PMID 22025992

Citations 5

Authors

Jelena Mirkovic

Condon Lau

Sasha McGee

Christopher Crum

Kamran Badizadegan

Michael Feld

Elizabeth Stier

Affiliations

Soon will be listed here.

Abstract

This study develops a spectroscopic algorithm for detection of cervical high grade squamous intraepithelial lesions (HSILs). We collected reflectance and fluorescence spectra with the quantitative spectroscopy probe to measure nine spectroscopic parameters from 43 patients undergoing standard colposcopy with directed biopsy. We found that there is improved accuracy for distinguishing HSIL from non-HSIL (low grade SIL and normal tissue) when we "normalized" spectroscopy parameters by dividing the values extracted from each clinically determined suspicious site by the corresponding value extracted from a clinically normal squamous site from the same patient. The "normalized" scattering parameter (A) at 700nm, best distinguished HSIL from non-HSIL with sensitivity and specificity of 89% and 79% suggesting that a simple, monochromatic instrument measuring only A may accurately detect HSIL.

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