Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Dec 10

PMID 34884737

Citations 10

Authors

Magdalena Kurnik-Lucka

Pawel Pasieka

Patrycja Laczak

Marcin Wojnarski

Michal Jurczyk

Krzysztof Gil

Affiliations

Soon will be listed here.

Abstract

Background: an increased prevalence of gastro-duodenal ulceration was described almost sixty years ago as prodromal to idiopathic Parkinson's disease, while duodenal ulcers have been rarely diagnosed in patients with schizophrenia. The cytoprotective role of dopamine in animal models of gastrointestinal ulcerations has also been described. Interestingly, Parkinson's disease (PD) might share common pathophysiological links with inflammatory bowel disease (IBD) as epidemiological and genetic links already suggest. Thus, the aim of our study was to review the existing literature on the role of the gastrointestinal dopaminergic system in IBD pathogenesis and progression.

Methods: a systematic search was conducted according to the PRISMA methodology.

Results: twenty-four studies satisfied the predetermined criteria and were included in our qualitative analysis. Due to different observations (cross-sectional studies) as well as experimental setups and applied methodologies (in vivo and in vitro studies) a meta-analysis could not be performed. No ongoing clinical trials with dopaminergic compounds in IBD patients were found.

Conclusions: the impairment of the dopaminergic system seems to be a significant, yet underestimated, feature of IBD, and more in-depth observational studies are needed to further support the existing preclinical data.

Citing Articles

Dopamine Receptors and TAAR1 Functional Interaction Patterns in the Duodenum Are Impaired in Gastrointestinal Disorders.

Vaganova A, Markina A, Belousov A, Lenskaia K, Gainetdinov R Biomedicines. 2024; 12(7).

PMID: 39062162 PMC: 11274761. DOI: 10.3390/biomedicines12071590.

Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin-Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions.

Khan N, Kurnik-Lucka M, Latacz G, Gil K Int J Mol Sci. 2024; 25(10).

PMID: 38791603 PMC: 11122119. DOI: 10.3390/ijms25105566.

Research progress on the roles of dopamine and dopamine receptors in digestive system diseases.

Lu X, Liu Q, Deng Y, Wu J, Mu X, Yang X J Cell Mol Med. 2024; 28(7):e18154.

PMID: 38494840 PMC: 10945074. DOI: 10.1111/jcmm.18154.

Gut commensals and their metabolites in health and disease.

Krishnamurthy H, Pereira M, Bosco J, George J, Jayaraman V, Krishna K Front Microbiol. 2023; 14:1244293.

PMID: 38029089 PMC: 10666787. DOI: 10.3389/fmicb.2023.1244293.

Effects of Vitamin E on the Gut Microbiome in Ageing and Its Relationship with Age-Related Diseases: A Review of the Current Literature.

Gothandapani D, Makpol S Int J Mol Sci. 2023; 24(19).

PMID: 37834115 PMC: 10572321. DOI: 10.3390/ijms241914667.

References

Asano Y, Hiramoto T, Nishino R, Aiba Y, Kimura T, Yoshihara K . Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice. Am J Physiol Gastrointest Liver Physiol. 2012; 303(11):G1288-95. DOI: 10.1152/ajpgi.00341.2012. View

Li Z, Schmauss C, Cuenca A, Ratcliffe E, Gershon M . Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice. J Neurosci. 2006; 26(10):2798-807. PMC: 6675162. DOI: 10.1523/JNEUROSCI.4720-05.2006. View

Vidal P, Pacheco R . Targeting the Dopaminergic System in Autoimmunity. J Neuroimmune Pharmacol. 2019; 15(1):57-73. DOI: 10.1007/s11481-019-09834-5. View

Willemze R, Welting O, van Hamersveld H, Meijer S, Folgering J, Darwinkel H . Neuronal control of experimental colitis occurs via sympathetic intestinal innervation. Neurogastroenterol Motil. 2017; 30(3). DOI: 10.1111/nmo.13163. View

Witoelar A, Jansen I, Wang Y, Desikan R, Gibbs J, Blauwendraat C . Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. JAMA Neurol. 2017; 74(7):780-792. PMC: 5710535. DOI: 10.1001/jamaneurol.2017.0469. View

Mayne C, Williams C . Induced and natural regulatory T cells in the development of inflammatory bowel disease. Inflamm Bowel Dis. 2013; 19(8):1772-88. PMC: 3690174. DOI: 10.1097/MIB.0b013e318281f5a3. View

Levandis G, Balestra B, Siani F, Rizzo V, Ghezzi C, Ambrosi G . Response of colonic motility to dopaminergic stimulation is subverted in rats with nigrostriatal lesion: relevance to gastrointestinal dysfunctions in Parkinson's disease. Neurogastroenterol Motil. 2015; 27(12):1783-95. DOI: 10.1111/nmo.12691. View

Mezey E, Palkovits M . Localization of targets for anti-ulcer drugs in cells of the immune system. Science. 1992; 258(5088):1662-5. DOI: 10.1126/science.1333642. View

Vaughan C, Aherne A, Lane E, Power O, Carey R, OConnell D . Identification and regional distribution of the dopamine D(1A) receptor in the gastrointestinal tract. Am J Physiol Regul Integr Comp Physiol. 2000; 279(2):R599-609. DOI: 10.1152/ajpregu.2000.279.2.R599. View

10.

Willemze R, Welting O, van Hamersveld P, Verseijden C, Nijhuis L, Hilbers F . Loss of intestinal sympathetic innervation elicits an innate immune driven colitis. Mol Med. 2019; 25(1):1. PMC: 6322236. DOI: 10.1186/s10020-018-0068-8. View

11.

Szabo S . Dopamine disorder in duodenal ulceration. Lancet. 1979; 2(8148):880-2. DOI: 10.1016/s0140-6736(79)92690-4. View

12.

Plichta D, Graham D, Subramanian S, Xavier R . Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships. Cell. 2019; 178(5):1041-1056. PMC: 6778965. DOI: 10.1016/j.cell.2019.07.045. View

13.

Chassaing B, Aitken J, Malleshappa M, Vijay-Kumar M . Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol. 2014; 104:15.25.1-15.25.14. PMC: 3980572. DOI: 10.1002/0471142735.im1525s104. View

14.

Eri R, McGuckin M, Wadley R . T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation. Methods Mol Biol. 2012; 844:261-75. DOI: 10.1007/978-1-61779-527-5_19. View

15.

Vieira-Coelho M, Teixeira V, Finkel Y, Soares-da-Silva P, Bertorello A . Dopamine-dependent inhibition of jejunal Na+-K+-ATPase during high-salt diet in young but not in adult rats. Am J Physiol. 1998; 275(6):G1317-23. DOI: 10.1152/ajpgi.1998.275.6.G1317. View

16.

Liu L, Wu Y, Wang B, Jiang Y, Lin L, Li X . DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization. Cell Death Dis. 2021; 12(6):500. PMC: 8129081. DOI: 10.1038/s41419-021-03778-6. View

17.

McCafferty D, Wallace J, Sharkey K . Effects of chemical sympathectomy and sensory nerve ablation on experimental colitis in the rat. Am J Physiol. 1997; 272(2 Pt 1):G272-80. DOI: 10.1152/ajpgi.1997.272.2.G272. View

18.

Miller C, Emmanuel A, Zarate-Lopez N, Taylor S, Bloom S . Constipation in ulcerative colitis: pathophysiology and practical management. Frontline Gastroenterol. 2021; 12(6):493-499. PMC: 8515272. DOI: 10.1136/flgastro-2020-101566. View

19.

Windsor J, Kaplan G . Evolving Epidemiology of IBD. Curr Gastroenterol Rep. 2019; 21(8):40. DOI: 10.1007/s11894-019-0705-6. View

20.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View