It Cuts Both Ways: Reconciling the Dual Roles of Caspase 8 in Cell Death and Survival

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2011 Oct 22

PMID 22016059

Citations 81

Authors

Andrew Oberst

Douglas R Green

Affiliations

Soon will be listed here.

Abstract

Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and immune cell proliferation. Recent work has indicated that the requirement for caspase 8 in development and immune cell proliferation is defined by suppression of receptor-interacting protein kinase 3 (RIPK3), a kinase that triggers an alternative form of cell death called programmed necrosis. Interestingly, these recent findings can be reconciled with earlier work on the non-apoptotic roles of caspase 8.

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