RIP1 Comes Back to Life As a Cell Death Regulator in TNFR1 Signaling

Overview

Journal FEBS J

Specialty Biochemistry

Date 2011 Jan 15

PMID 21232018

Citations 26

Authors

Marie Anne ODonnell

Adrian T Ting

Affiliations

Soon will be listed here.

Abstract

Cell death induction by tumor necrosis factor has been an intensively studied area for the last two decades. Although it may appear that the skeleton should have been picked clean by now, new secrets about tumor necrosis factor death signaling are still being uncovered. In particular, the recent evidence that ubiquitination of the death kinase receptor-interacting protein 1 regulates its participation in apoptotic and necrotic cell death is opening up unexplored avenues in the catacombs of tumor necrosis factor death signaling. In this minireview, we focus on two major cell-death checkpoints that determine whether receptor-interacting protein 1 functions as a pro-survival or pro-death molecule.

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