Vanadium Bromoperoxidase from Delisea Pulchra: Enzyme-catalyzed Formation of Bromofuranone and Attendant Disruption of Quorum Sensing

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2011 Oct 19

PMID 22006105

Citations 12

Authors

Moriah Sandy

Jayme N Carter-Franklin

Jessica D Martin

Alison Butler

Affiliations

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Abstract

Vanadium bromoperoxidase was isolated and cloned from the marine red alga Delisea pulchra. This enzyme catalyzes the bromolactonization of 4-pentynoic acid forming 5E-bromo-methylidenetetrahydro-2-furanone, a compound which is shown herein to inhibit quorum sensing in the engineered reporter strain, Agrobacterium tumefaciens NTL4.

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