High-frequency Oscillations and Other Electrophysiological Biomarkers of Epilepsy: Clinical Studies

Overview

Journal Biomark Med

Specialties Biochemistry
General Medicine

Date 2011 Oct 19

PMID 22003904

Citations 65

Authors

Greg Worrell

Jean Gotman

Affiliations

Soon will be listed here.

Abstract

Accurate localization of epileptogenic brain is critical for successful epilepsy surgery. Recent research using wide bandwidth intracranial EEG has demonstrated that interictal high-frequency oscillations are preferentially localized to the brain region generating spontaneous seizures, and are a potential biomarker of epileptogenic brain. The existence of an interictal, electrophysiological biomarker of epileptogenic brain has the potential to significantly advance epilepsy surgery by improving outcomes through improved localization and potentially eliminating the reliance on chronic intracranial EEG monitoring.

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References

Chatillon C, Zelmann R, Bortel A, Avoli M, Gotman J . Contact size does not affect high frequency oscillation detection in intracerebral EEG recordings in a rat epilepsy model. Clin Neurophysiol. 2011; 122(9):1701-5. PMC: 3753291. DOI: 10.1016/j.clinph.2011.02.022. View

Zelmann R, Mari F, Jacobs J, Zijlmans M, Dubeau F, Gotman J . A comparison between detectors of high frequency oscillations. Clin Neurophysiol. 2011; 123(1):106-16. PMC: 3782488. DOI: 10.1016/j.clinph.2011.06.006. View

Hoogenboom N, Schoffelen J, Oostenveld R, Parkes L, Fries P . Localizing human visual gamma-band activity in frequency, time and space. Neuroimage. 2005; 29(3):764-73. DOI: 10.1016/j.neuroimage.2005.08.043. View

Stead M, Bower M, Brinkmann B, Lee K, Marsh W, Meyer F . Microseizures and the spatiotemporal scales of human partial epilepsy. Brain. 2010; 133(9):2789-97. PMC: 2929333. DOI: 10.1093/brain/awq190. View

Urrestarazu E, Jirsch J, Levan P, Hall J, Avoli M, Dubeau F . High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikes. Epilepsia. 2006; 47(9):1465-76. DOI: 10.1111/j.1528-1167.2006.00618.x. View

Jirsch J, Urrestarazu E, LeVan P, Olivier A, Dubeau F, Gotman J . High-frequency oscillations during human focal seizures. Brain. 2006; 129(Pt 6):1593-608. DOI: 10.1093/brain/awl085. View

Spencer S, Goncharova I, Duckrow R, Novotny E, Zaveri H . Interictal spikes on intracranial recording: behavior, physiology, and implications. Epilepsia. 2008; 49(11):1881-92. DOI: 10.1111/j.1528-1167.2008.01641.x. View

Bragin A, Mody I, Wilson C, Engel Jr J . Local generation of fast ripples in epileptic brain. J Neurosci. 2002; 22(5):2012-21. PMC: 6758883. View

Shmuel A, Leopold D . Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest. Hum Brain Mapp. 2008; 29(7):751-61. PMC: 6870786. DOI: 10.1002/hbm.20580. View

10.

Bragin A, Wilson C, Engel Jr J . Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis. Epilepsia. 2000; 41 Suppl 6:S144-52. DOI: 10.1111/j.1528-1157.2000.tb01573.x. View

11.

Gardner A, Worrell G, Marsh E, Dlugos D, Litt B . Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings. Clin Neurophysiol. 2007; 118(5):1134-43. PMC: 2020804. DOI: 10.1016/j.clinph.2006.12.019. View

12.

Blanco J, Stead M, Krieger A, Viventi J, Marsh W, Lee K . Unsupervised classification of high-frequency oscillations in human neocortical epilepsy and control patients. J Neurophysiol. 2010; 104(5):2900-12. PMC: 2997042. DOI: 10.1152/jn.01082.2009. View

13.

Schevon C, Trevelyan A, Schroeder C, Goodman R, McKhann Jr G, Emerson R . Spatial characterization of interictal high frequency oscillations in epileptic neocortex. Brain. 2009; 132(Pt 11):3047-59. PMC: 2768661. DOI: 10.1093/brain/awp222. View

14.

Mukamel R, Gelbard H, Arieli A, Hasson U, Fried I, Malach R . Coupling between neuronal firing, field potentials, and FMRI in human auditory cortex. Science. 2005; 309(5736):951-4. DOI: 10.1126/science.1110913. View

15.

Urrestarazu E, Chander R, Dubeau F, Gotman J . Interictal high-frequency oscillations (100-500 Hz) in the intracerebral EEG of epileptic patients. Brain. 2007; 130(Pt 9):2354-66. DOI: 10.1093/brain/awm149. View

16.

Worrell G, Gardner A, Matt Stead S, Hu S, Goerss S, Cascino G . High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings. Brain. 2008; 131(Pt 4):928-37. PMC: 2760070. DOI: 10.1093/brain/awn006. View

17.

Saab M, Gotman J . A system to detect the onset of epileptic seizures in scalp EEG. Clin Neurophysiol. 2005; 116(2):427-42. DOI: 10.1016/j.clinph.2004.08.004. View

18.

Moeller F, Tyvaert L, Nguyen D, LeVan P, Bouthillier A, Kobayashi E . EEG-fMRI: adding to standard evaluations of patients with nonlesional frontal lobe epilepsy. Neurology. 2009; 73(23):2023-30. PMC: 2881856. DOI: 10.1212/WNL.0b013e3181c55d17. View

19.

Traub R, Whittington M, Buhl E, LeBeau F, Bibbig A, Boyd S . A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia. 2001; 42(2):153-70. DOI: 10.1046/j.1528-1157.2001.26900.x. View

20.

BERTRAND . Oscillatory gamma activity in humans and its role in object representation. Trends Cogn Sci. 1999; 3(4):151-162. DOI: 10.1016/s1364-6613(99)01299-1. View