Hiding in Plain Sight: How HIV Evades Innate Immune Responses

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2011 Oct 18

PMID 22000008

Citations 35

Authors

Nicolas Manel

Dan R Littman

Affiliations

Soon will be listed here.

Abstract

Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutières Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.

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